Journal ArticleDOI
Optical Coherence Tomography of the Human Retina
Michael R. Hee,Joseph A. Izatt,Eric A. Swanson,David Huang,Joel S. Schuman,Charles P. Lin,Carmen A. Puliafito,James G. Fujimoto +7 more
TLDR
In this paper, optical coherence tomography is used for high-resolution, noninvasive imaging of the human retina, including the macula and optic nerve head in normal human subjects.Abstract:
Objective: To demonstrate optical coherence tomography for high-resolution, noninvasive imaging of the human retina. Optical coherence tomography is a new imaging technique analogous to ultrasound B scan that can provide cross-sectional images of the retina with micrometer-scale resolution. Design: Survey optical coherence tomographic examination of the retina, including the macula and optic nerve head in normal human subjects. Setting: Research laboratory. Participants: Convenience sample of normal human subjects. Main Outcome Measures: Correlation of optical coherence retinal tomographs with known normal retinal anatomy. Results: Optical coherence tomographs can discriminate the cross-sectional morphologic features of the fovea and optic disc, the layered structure of the retina, and normal anatomic variations in retinal and retinal nerve fiber layer thicknesses with 10-??m depth resolution. Conclusion: Optical coherence tomography is a potentially useful technique for high depth resolution, cross-sectional examination of the fundus.read more
Citations
More filters
Journal ArticleDOI
Optical Coherence Tomography
TL;DR: The optical coherence tomograph is a new, noninvasive technical device that can obtain cross-sectional, high-resolution images-optical coherencetomographs (OCT)-of the retina that permits an accurate evaluation of various macular and chorioretinal pathologies and the early detection of glaucomatous damage.
Journal ArticleDOI
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Mark E. Brezinski,Brett E. Bouma,Brett E. Bouma,Stephen A. Boppart,Stephen A. Boppart,Costas Pitris,Costas Pitris,James F. Southern,James F. Southern,James G. Fujimoto,James G. Fujimoto +12 more
TL;DR: Optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, and was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.
Journal ArticleDOI
Optical coherence tomography (OCT): a review
TL;DR: The state of the art of optical coherence tomography (OCT), an interferometric imaging technique that provides cross-sectional views of the subsurface microstructure of biological tissue is reviewed.
Journal ArticleDOI
Imaging of macular diseases with optical coherence tomography.
Carmen A. Puliafito,Michael R. Hee,Charles P. Lin,Elias Reichel,Joel S. Schuman,Jay S. Duker,Joseph A. Izatt,Eric A. Swanson,James G. Fujimoto +8 more
TL;DR: Optical coherence tomography is potentially a powerful tool for detecting and monitoring a variety of macular diseases, including macular edema, macular holes, and detachments of the neurosensory retina and pigment epithelium.
Journal ArticleDOI
Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation.
Maciej Wojtkowski,Vivek J. Srinivasan,Tony H. Ko,James G. Fujimoto,Andrzej Kowalczyk,Jay S. Duker +5 more
TL;DR: High-resolution spectral domain OCT is shown to provide a ~100x increase in imaging speed when compared to ultrahigh-resolution time domain OCT, and a general technique for automatic numerical dispersion compensation is presented, which is applicable to spectral domain as well as swept source embodiments of Fourier domain OCT.
References
More filters
Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Journal ArticleDOI
Optic Nerve Damage in Human Glaucoma: III. Quantitative Correlation of Nerve Fiber Loss and Visual Field Defect in Glaucoma, Ischemic Neuropathy, Papilledema, and Toxic Neuropathy
TL;DR: The pattern of atrophy in examples of toxic amblyopia, ischemic optic neuropathy and chronic papilledema differ from that of glaucoma, suggesting different mechanisms of damage in these conditions.
Journal ArticleDOI
In vivo retinal imaging by optical coherence tomography.
Eric A. Swanson,Joseph A. Izatt,Michael R. Hee,David Huang,Charles P. Lin,Joel S. Schuman,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: These images represent the highest depth resolution in vivo retinal images to date and are to the authors' knowledge the first in vivo measurements of human retinal structure with optical coherence tomography.
Journal ArticleDOI
Optical coherence-domain reflectometry: a new optical evaluation technique.
TL;DR: An optical evaluation technique is described that is suitable for determining the positions and magnitudes of reflection sites within miniature optical assemblies using the coherence effects exhibited by a broadband optical source and is referred to as optical coherence-domain reflectometry.
Journal ArticleDOI
Clinical use of ultrasound biomicroscopy
TL;DR: Clinical ultrasound biomicroscopy (UBM) has shown significant potential as an aid in diagnoses of ocular disease and the ability to define the relationship of the iris, posterior chamber, zonules, ciliary body, and lens is potentially helpful in understanding mechanisms of glaucoma.