Original Investigations Psychotropic Drug Influences on Brain Acetylcholine Utilization

TLDR: It was found that psyehotropie drugs have marked differen- tial effects on the rate of I-IC-3 induced ACh depletion.

Abstract: The cholinergic antisynthesis agent HC-3 was given intraventricularly to young male rats 20--30 days old to deplete brain aeetylcholine (ACh). The rate of ~C-3 induced depletion of ACh was used as an index of ACh utilization. Total brain ACh was determined following various doses of ehlordiazepoxide, pentobarbi- tal, ehlorprom~zine, methotrimeprazine, imipramine, morphine, d-amphetamine, scopolamine, LSD-25, and phencyelidine give~l i.p. alone and after intraventrieular administration of I-IC-3. It was found that psyehotropie drugs have marked differen- tial effects on the rate of I-IC-3 induced ACh depletion.