Oxidation of clindamycin phosphate by chromium(VI) in aqueous sulfuric acid medium—A kinetic and mechanistic study
TLDR
In this article, the mechanism of clindamycin phosphate by potassium dichromate in aqueous sulfuric acid medium is studied spectrophotometrically at 25°C at a constant ionic strength of 3.60 m−DM−3.Abstract:
Kinetics and mechanism of oxidation of clindamycin phosphate by potassium dichromate in aqueous sulfuric acid medium is studied spectrophotometrically at 25°C at a constant ionic strength of 3.60 mol dm−3. The stoichiometry of the reaction is determined and it was found that one mole of clindamycin phosphate consumes two moles of chromium(VI) (1:2). The oxidation products are characterized and confirmed by spectral studies such as IR, GC-MS and LC-MS. The reaction is first order each in chromium(VI) and clindamycin phosphate concentrations. An increase in the sulfuric acid concentration causes an increase of the reaction rate. The order with respect to acid concentration is found to be 1.65. From the results of kinetic studies, reaction stoichiometry and product analysis a suitable free radical mechanism is proposed. Based on investigation of the reaction at different temperatures, computation of the activation parameters with respect to the slow step of the proposed mechanism was evaluated.read more
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Theoretical inorganic chemistry
TL;DR: In this paper, the photochemical reactions of coordination compounds are described. But they do not consider the effects of transition metals on coordination compounds, such as diazenes and diazo compounds.
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Treatment of Toxoplasmic Encephalitis in Patients with AIDS
Brian R. Dannemann,J. Allen McCutchan,Dennis Israelski,Diane Antoniskis,Catherine Leport,Benjamin J. Luft,J Nussbaum,Nathan Clumeck,Philippe Morlat,J Chiu,Jean-Louis Vildé,Manuel A. Orellana,David W. Feigal,Angie E. Bartok,Peter N.R. Heseltine,John M. Leedom,Jack S. Remington +16 more
TL;DR: In this paper, the authors compared pyrimethamine plus clindamycin (PC) to pyrithmine plus sulfadiazine (PS) as a treatment for toxoplasmic encephalitis (TE) in patients with the acquired immunodefic...
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Review on Kinetic and Thermal Study of Oxidation and Degradation of Medicinal Drug
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CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
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Vogel's textbook of quantitative chemical analysis
TL;DR: In this paper, the principles of reaction in solution are discussed and the basis of separarative methods are discussed, as well as the safety units of Reagent Purity and Reagent Reactions in Solution.
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Treatment of Toxoplasmic Encephalitis in Patients with AIDS: A Randomized Trial Comparing Pyrimethamine plus Clindamycin to Pyrimethamine plus Sulfadiazine
Brian R. Dannemann,J A McCutchan,Dennis Israelski,D Antoniskis,Catherine Leport,Benjamin J. Luft,J Nussbaum,Nathan Clumeck,Philippe Morlat,J Chiu +9 more
TL;DR: PC appears to be an acceptable alternative in patients unable to tolerate PS, and the results of several end points of efficacy suggest that the relative efficacy of PC approximately equals that of PS.
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A common misconception about the Eyring equation
TL;DR: Linearization and direct fitting to the Eyring equation have been shown to give the entropy of activation with the same reliability as that of the enthalpy of activation as discussed by the authors, which is the state of the art.