J
John M. Leedom
Researcher at University of Southern California
Publications - 85
Citations - 7241
John M. Leedom is an academic researcher from University of Southern California. The author has contributed to research in topics: Meningitis & Ampicillin. The author has an hindex of 35, co-authored 85 publications receiving 7167 citations. Previous affiliations of John M. Leedom include University of California, San Diego & University of Pennsylvania.
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Journal ArticleDOI
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex: a double-blind placebo-controlled trial.
Margaret A. Fischl,Douglas D. Richman,M. H. Grieco,M. S. Gottlieb,Paul A. Volberding,Oscar L. Laskin,John M. Leedom,Jerome E. Groopman,Donna Mildvan,Robert T. Schooley +9 more
TL;DR: It is demonstrated that AZT administration can decrease mortality and the frequency of opportunistic infections in a selected group of subjects with AIDS or AIDS-related complex, at least over the 8 to 24 weeks of observation in this study.
Journal ArticleDOI
Nevirapine, Zidovudine, and Didanosine Compared with Zidovudine and Didanosine in Patients with HIV-1 Infection: A Randomized, Double-Blind, Placebo-Controlled Trial
Richard T. D'Aquila,Michael Hughes,Victoria A. Johnson,Margaret A. Fischl,Jean Pierre Sommadossi,Song Heng Liou,Joseph Timpone,Maureen Myers,Nesli Basgoz,Manette T. Niu,Martin S. Hirsch,Michael S. Saag,Jill Weingarten,John W. Gnann,Diane V. Havlir,Chris Fegan,Stephen A. Spector,Douglas D. Richman,Mark A. Jacobson,Kathy Dybeck,Patrick Joseph,Kathleen Clanon,Stacey McKenzie,Pam Daniel,Dale Dayton,Jill Leonard,Robert Schooley,Daniel Kuritzkes,Graham Ray,Beverly Putnam,Dushyantha Jayaweera,Janie Patrone-Reese,Thomas Tanner,Jo Moebus,Nancy Reed,Renee St Jacque,Keith Henry,Susan Swindells,Joe Eron,David Ragan,James Horton,Timothy G. Lane,Ian Frank,Anne Norris,Roger Pomerantz,Stephen Hauptman,Jan Geiseler,John M. Leedom,Frances Canchola,Connie Olson,Lawrence Deyton,Carla Pettinelli +51 more
TL;DR: This multicenter, randomized trial was AIDS (acquired immunodeficiency syndrome) and tested whether this triple combination would improve immunologic and virologic effects in vivo by comparing it with a combination of zidovudine and didanosine in a 48-week phase II, randomized clinical trial in adults with HIV-1 disease who had previously received prolonged nucleoside therapy.
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Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus.
Darryl Shibata,William J. Martin,M D Appleman,Dennis M. Causey,John M. Leedom,Norman Arnheim +5 more
TL;DR: The CMV PCR was more sensitive than the standard culture assay, can be completed in one to two days, uses only 20 microL of blood, and may be useful for rapidly detecting CMV in clinical specimens.
Journal ArticleDOI
Protease inhibitor-associated hyperglycaemia.
Journal ArticleDOI
Delayed diagnosis of tuberculosis in patients with human immunodeficiency virus infection.
TL;DR: Delayed therapy of tuberculosis in HIV-infected patients with culture-proven tuberculosis seen at a 1,900-bed general hospital serving a predominantly indigent population in Los Angeles was common and was not due to atypical manifestations of tuberculosis.