Journal ArticleDOI
Paleolithic vs. modern diets--selected pathophysiological implications.
S B Eaton,S B Eaton rd +1 more
TLDR
This review addressed phytochemicals and cancer; calcium, physical exertion, bone mineral density and bone structural geometry; dietary protein, potassium, renal acid secretion and urinary calcium loss; and finally sarcopenia, adiposity, insulin receptors and insulin resistance.Abstract:
The nutritional patterns of Paleolithic humans influenced genetic evolution during the time segment within which defining characteristics of contemporary humans were selected. Our genome can have changed little since the beginnings of agriculture, so, genetically, humans remain Stone Agers--adapted for a Paleolithic dietary regimen. Such diets were based chiefly on wild game, fish and uncultivated plant foods. They provided abundant protein; a fat profile much different from that of affluent Western nations; high fibre; carbohydrate from fruits and vegetables (and some honey) but not from cereals, refined sugars and dairy products; high levels of micronutrients and probably of phytochemicals as well. Differences between contemporary and ancestral diets have many pathophysiological implications. This review addresses phytochemicals and cancer; calcium, physical exertion, bone mineral density and bone structural geometry; dietary protein, potassium, renal acid secretion and urinary calcium loss; and finally sarcopenia, adiposity, insulin receptors and insulin resistance. While not, yet, a basis for formal recommendations, awareness of Paleolithic nutritional patterns should generate novel, testable hypotheses grounded in evolutionary theory and it should dispel complacency regarding currently accepted nutritional tenets.read more
Citations
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Journal ArticleDOI
Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases.
TL;DR: Chronic exposure to a high-salt diet appears to be a major factor involved in the frequent occurrence of hypertension and cardiovascular diseases in human populations.
Journal ArticleDOI
Magnesium: nutrition and metabolism.
TL;DR: Due to the growing knowledge about the regulation of extra- and intracellular magnesium concentrations and the effects of changed extracellular magnesium levels the use of magnesium in therapy gains more widespread attention.
Journal ArticleDOI
Sodium intake and hypertension.
TL;DR: The biologic rationale and scientific evidence show that the current salt intake levels largely explain the high prevalence of hypertension, and comprehensive reduction of salt intake, both alone and particularly in combination with increases in intakes of potassium, calcium, and magnesium, is able to lower average blood pressure levels substantially.
Book
The Fetal Matrix: Evolution, Development and Disease
Peter D. Gluckman,Mark A. Hanson +1 more
TL;DR: Synthesising developmental biology, evolutionary history, medical science, public health and social policy, this is a ground-breaking and fascinating account by two of the world's leading pioneers in this important emerging field.
ORIGINAL COMMUNICATION The paradoxical nature of hunter-gatherer diets: meat-based, yet non-atherogenic
TL;DR: In this paper, the authors analyzed the 13 known quantitative dietary studies of hunter-gathers and demonstrated that animal food actually provided the dominant energy source, while gathered plant foods comprised the remainder (35%).
Related Papers (5)
Paleolithic nutrition: a consideration of its nature and current implications
S B Eaton,Melvin Konner +1 more