Journal ArticleDOI
Passive multi-frequency brain imaging and hyperthermia irradiation apparatus: the use of dielectric matching materials in phantom experiments
TLDR
In this paper, a hybrid system able to provide focused microwave radiometry and deep brain hyperthermia is experimentally tested using water phantoms surrounded by dielectric layers used as matching material to enhance detection/penetration depth and spatial resolution.Abstract:
In this paper a hybrid system able to provide focused microwave radiometry and deep brain hyperthermia is experimentally tested. The system's main module is an ellipsoidal conductive wall cavity which acts as a beam former, focusing the electromagnetic energy on the medium of interest. The system's microwave radiometry component has extensively been studied theoretically and experimentally in the past few years with promising results. In this work, further investigation concerning the improvement of the hybrid system's focusing properties is conducted. Specifically, microwave radiometry and hyperthermia experiments are performed using water phantoms surrounded by dielectric layers used as matching material to enhance detection/penetration depth and spatial resolution. The results showed that the dielectric material reduces the reflected electromagnetic energy on the air–phantom interface, resulting in improved temperature resolution and higher detection or penetration of the energy when microwave radiometry and hyperthermia are applied respectively.read more
Citations
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Journal ArticleDOI
Noninvasive Focused Monitoring and Irradiation of Head Tissue Phantoms at Microwave Frequencies
K.T. Karathanasis,I. A. Gouzouasis,I.S. Karanasiou,Melpomeni Giamalaki,George E. Stratakos,Nikolaos K. Uzunoglu +5 more
TL;DR: The present results show that the system is able to detect local concentrated gradual temperature and conductivity variations expressed as an increase of the output radiometric voltage, and when contactless focused hyperthermia is performed, the results show significant temperature increase at specific phantom areas.
Journal ArticleDOI
Prospects for radiofrequency hyperthermia applicator research. I--Pre-optimised prototypes of endocavitary applicators with matching interfaces for prostate hyperplasia and cancer treatments.
TL;DR: Assessment of new RF radiators with controlled dielectric matching interfaces for evaluating the potential of RF radiation in EHT and in interstitial hyperthermia (IHT) treatments reveal features such as customisable length and shape, independence of insertion depth, uncritical air gap, longitudinal heating uniformity, outstanding penetration depths and high SAR gradients at both radiator ends.
Proceedings ArticleDOI
Combining reflector focused and phased array beamforming for microwave diagnosis and therapy
TL;DR: Four element antenna setups are used and extensive simulations to compute the electric field distributions inside the whole ellipsoidal reflector and inside two types of human head models were carried out and show that clear focusing (creation of “hot spots”) inside the head models is achieved at 1GHz.
Book ChapterDOI
Towards Multispectral Multimodal Non-ionising Diagnosis and Therapy
TL;DR: This chapter will review the progress in diagnostic, therapeutic and theranostic multi-modal multispectral methods, with specific attention to cerebrovascular diseases and monitoring of the brain activity.
Journal ArticleDOI
Imaging of Conductivity Changes of Excitable Tissues Based on Focused Passive Microwave.
TL;DR: The theoretical analysis of ion charge diffusion during the cycle of action potentials, propagating along the axons in case of measurements of specific cortical regions is presented and it is concluded that the microwave radiometry output voltage is not affected by the temporal and spatial average fluctuations of Na+, K+, and Cl- ions of neural cell axons.
References
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Hyperthermia in combined treatment of cancer
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TL;DR: For every particular temperature-dependent interaction exploited for clinical purposes, sophisticated control of temperature, spatially as well as temporally, in deep body regions will further improve the potential.
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Heating the patient: a promising approach?
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TL;DR: The purpose of this article is to provide an overview on the current clinical application of hyperthermia combined with conventional treatment modalities (e.g. ionizing radiation, chemotherapy) in the treatment of malignant disease.
Journal ArticleDOI
Noninvasive estimation of tissue temperature response to heating fields using diagnostic ultrasound
R. Seip,Emad S. Ebbini +1 more
TL;DR: A noninvasive technique for monitoring tissue temperature changes due to heating fields using diagnostic ultrasound is described, based on the discrete scattering model used in the tissue characterization literature and the observation that most biological tissues are semi-regular scattering lattices.