Journal ArticleDOI
Pathogenesis of Hepatic Encephalopathy-with Special Reference to the Role of Ammonia
Charles O. Walker,S Schenker +1 more
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This article is published in The American Journal of Clinical Nutrition.The article was published on 1970-05-01. It has received 108 citations till now. The article focuses on the topics: Encephalopathy & Hepatic encephalopathy.read more
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Quantitative tests of nitrogen metabolism in cirrhosis: relation to other manifestations of liver disease.
Joseph D. Ansley,James W. Isaacs,Layton F. Rikkers,Michael Kutner,Bernard M. Nordlinger,Daniel Rudman +5 more
TL;DR: Nitrogen metabolism and hepatic function were comprehensively evaluated in 73 patients with cirrhosis, portal hypertension, and history of variceal hemorrhage, and in 18 normal controls.
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Cerebral glucose metabolism after portacaval shunting in the rat. Patterns of metabolism and implications for the pathogenesis of hepatic encephalopathy.
TL;DR: Visual inspection of autoradiograms, computed correlation coefficients relating interregional metabolism, and principal component analysis suggest that normal cerebral metabolic and functional interrelationships are altered by shunting.
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Experimental spongy degeneration in calves.
D. Y. Cho,H. W. Leipold +1 more
TL;DR: Experimental reproduction and ultrastructural findings of spongy degeneration of the central nervous system of hyperammonemic calves are described, suggesting Hyperammonemia may be one of the pathogeneses involved in the CNS sponged degeneration in man and domestic animals affected with hepatocerebral diseases and some hereditary disorders.
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Methionine-induced hepatic coma in dogs.
TL;DR: The methionine-induced coma closely reproduces the clinical and electroencephalographic picture of coma in other canine models and the concept of the synergistic effect with ammonia may lead to a clearer understanding of certain enterogenous and dietetic forms of hepatic encephalopathy in cirrhotic patients.
Journal ArticleDOI
An Experimental Model for the Study of Hepatic Encephalopathy
TL;DR: A subacute experimental model of hepatic encephalopathy was created in the rat by constructing a portacaval shunt with subsequent gavage feeding of a cationic ammonium exchange resin, and proliferation of Alzeimer type II astrocytes in the cerebral cortex was demonstrated.