Quantitative tests of nitrogen metabolism in cirrhosis: relation to other manifestations of liver disease.
Joseph D. Ansley,James W. Isaacs,Layton F. Rikkers,Michael Kutner,Bernard M. Nordlinger,Daniel Rudman +5 more
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TLDR
Nitrogen metabolism and hepatic function were comprehensively evaluated in 73 patients with cirrhosis, portal hypertension, and history of variceal hemorrhage, and in 18 normal controls.About:
This article is published in Gastroenterology.The article was published on 1978-10-01 and is currently open access. It has received 49 citations till now. The article focuses on the topics: Hepatic encephalopathy & Cirrhosis.read more
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The Emory prospective randomized trial: selective versus nonselective shunt to control variceal bleeding. Ten year follow-up.
William J. Millikan,W. D. Warren,J. M. Henderson,R B Smith rd,Atef A. Salam,J T Galambos,Michael Kutner,J H Keen +7 more
TL;DR: There was less rebleeding and encephalopathy after distal splenorenal shunt; postoperative portal perfusion and hepatic function were maintained; and improved survival was confirmed in nonalcoholics.
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Synthesis of urea after stimulation with amino acids: relation to liver function.
TL;DR: Observations imply that a given urea synthesis rate requires a higher alpha-amino level in patients with reduced liver function, while confirming the abundant capacity of the Urea synthesis system.
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Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonaemia in chronic liver disease.
TL;DR: The data suggest that hyperbicarbonataemia in chronic liver disease may, amongst other effects, be due to an impaired hepatic HCO3‐ removal by urea synthesis, in line with the concept of a role of the liver in systemic acid–base homeostasis.
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Hypotyrosinemia, Hypocystinemia, and Failure to Retain Nitrogen During Total Parenteral Nutrition of Cirrhotic Patients
Daniel Rudman,Michael Kutner,Joseph D. Ansley,Robert D. Jansen,Jacques Chipponi,Raymond P. Bain +5 more
TL;DR: Six patients with gastrointestinal malabsorption and 12 with alcoholic cirrhosis received total parenteral nutrition for 4 wk and it is concluded that in 4 cirrhotics, repletion was blocked by deficiencies of cystine and tyrosine, resulting from hepatic inability to synthesize Cystine from methionine and Tyrosine from phenylalanine.
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Plasma glutamine concentration: a guide in the management of urea cycle disorders.
TL;DR: It is suggested that one goal of therapy is the maintenance of plasma glutamine levels at or near normal values, as increases in plasma glutamines are almost always associated with hyperammonemia in patients with urea cycle disorders.
References
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Albumin standards and the measurement of serum albumin with bromcresol green
TL;DR: The results by this method agree very well with those obtained by electrophoresis and salt fractionation and the method is simple, it has excellent precision and the reagents are stable.
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Adaptive characteristics of urea cycle enzymes in the rat.
TL;DR: Investigation into the mechanisms by means of which the rate of urea synthesis is altered in response to differences in dietary protein consumption indicate that adaptation to differing consumption of protein involves changes in activities of all urea cycle enzymes in the liver.