scispace - formally typeset
Journal ArticleDOI

Pattern of lymph node metastasis spread in pancreatic cancer.

Mitsuro Kanda, +12 more
- 01 Aug 2011 - 
- Vol. 40, Iss: 6, pp 951-955
Reads0
Chats0
TLDR
Aggressive multimodality therapy, including neoadjuvant therapy, is essential to improve the long-term survival of patients at substantial risk of distant LN metastasis, via a complex pathway and developed into systemic disease.
Abstract: 
Objectives:We aimed to clarify the detailed pattern of lymph node (LN) metastasis spread in patients with pancreatic cancer.Methods:This retrospective study enrolled 429 patients who underwent pancreatectomy with extended lymphadenectomy for pancreatic cancer. The prognostic implications of LN metas

read more

Citations
More filters
Journal ArticleDOI

Only women with symptoms need to have their breast implants removed, says government

Bond-Smith Giles, +5 more
- 18 Apr 2012 - 
Journal ArticleDOI

Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS).

Johanna A. M. G. Tol, +23 more
- 01 Sep 2014 - 
TL;DR: Standard lymphadenectomy for pancreatoduodenectomy should strive to resect Ln stations no. 5, 6, 8a, 12b1,12b2, 12c, 13a, 13b, 14a, 14b, 17a, and 17b, for cancers of the body and tail of the pancreas, removal of stations 10, 11, and 18 is standard.
Journal ArticleDOI

Radical surgery of oligometastatic pancreatic cancer.

T. Hackert, +7 more
- 01 Feb 2017 - 
TL;DR: The present collective is the largest series of resected metastatic PDAC and shows that resection of liver or ILN metastases can be done safely and should be considered as it may be superior to palliative treatment, and it is associated with long-term survival of 10% in selected patients.
Journal ArticleDOI

Substaging of Lymph Node Status in Resected Pancreatic Ductal Adenocarcinoma Has Strong Prognostic Correlations: Proposal for a Revised N Classification for TNM Staging.

Olca Basturk, +17 more
- 11 Sep 2015 - 
TL;DR: Substaging of LN metastasis has significant prognostic value and needs to be considered in the N staging of PDACs, and the protocol already in use for other upper GI tract organs, which currently also is proven significant for ampulla, would be preferable.
Journal ArticleDOI

M2-polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancer.

Hiroshi Kurahara, +11 more
- 01 Jan 2013 - 
TL;DR: In this article, the authors investigated the relationship of M2-polarized TAM infiltration of the RLNs, nodal lymphangiogenesis, and occult nodal involvement in pN0 pancreatic cancer.
References
More filters
Journal ArticleDOI

Cancer statistics, 2007.

Ahmedin Jemal, +5 more
- 01 Jan 2007 - 
TL;DR: While the absolute number of cancer deaths decreased for the second consecutive year in the United States, much progress has been made in reducing mortality rates and improving survival, cancer still accounts for more deaths than heart disease in persons under age 85 years.
Journal ArticleDOI

Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial.

Helmut Oettle, +19 more
- 17 Jan 2007 - 
TL;DR: The results support the use of gemcitabine as adjuvant chemotherapy in resectable carcinoma of the pancreas by significantly delayed the development of recurrent disease after complete resection of pancreatic cancer compared with observation alone.
Journal ArticleDOI

Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group.

Sergio Pedrazzoli, +8 more
- 01 Oct 1998 - 
TL;DR: The addition of an extended lymphadenectomy and retroperitoneal soft-tissue clearance to a pancreatoduodenal resection does not significantly increase morbidity and mortality rates, and overall survival does not differ between the two groups.
Journal ArticleDOI

Prognostic Factors Following Curative Resection for Pancreatic Adenocarcinoma: A Population-Based, Linked Database Analysis of 396 Patients

Jonathan E. Lim, +2 more
- 01 Jan 2003 - 
TL;DR: Although biologic characteristics remain important predictors of survival for patients with resected pancreatic cancer, the most powerful determinant is postoperative adjuvant chemoradiation therapy.
Journal ArticleDOI

A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma.

Michael B. Farnell, +7 more
- 01 Oct 2005 - 
TL;DR: Both the decrement in quality of life and similar studies showing no survival difference make PD/ELND unattractive for further prospective investigation.
Related Papers (5)

Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: a consensus statement by the International Study Group on Pancreatic Surgery (ISGPS).

Johanna A. M. G. Tol, +23 more
- 01 Sep 2014 - 

Standard versus extended lymphadenectomy in radical pancreatoduodenectomy for ductal adenocarcinoma of the head of the pancreas: long-term results of a Japanese multicenter randomized controlled trial.

Yuji Nimura, +14 more
- 01 May 2012 - 

Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group.

Sergio Pedrazzoli, +8 more
- 01 Oct 1998 - 

A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma.

Michael B. Farnell, +7 more
- 01 Oct 2005 - 

Impact of Total Lymph Node Count and Lymph Node Ratio on Staging and Survival after Pancreatectomy for Pancreatic Adenocarcinoma: A Large, Population-Based Analysis

Mark B. Slidell, +7 more
- 01 Jan 2008 -