L
Lawrence J. Burgart
Researcher at Mayo Clinic
Publications - 212
Citations - 29716
Lawrence J. Burgart is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Cancer & Microsatellite instability. The author has an hindex of 80, co-authored 212 publications receiving 28270 citations. Previous affiliations of Lawrence J. Burgart include Fox Chase Cancer Center & Abbott Northwestern Hospital.
Papers
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Journal ArticleDOI
Revised Bethesda Guidelines for Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) and Microsatellite Instability
Asad Umar,C. Richard Boland,Jonathan P. Terdiman,Sapna Syngal,Albert de la Chapelle,Josef Rüschoff,Richard Fishel,Noralane M. Lindor,Lawrence J. Burgart,Richard Hamelin,Stanley R. Hamilton,Robert A. Hiatt,Jeremy R. Jass,Annika Lindblom,Henry T. Lynch,Päivi Peltomäki,Scott D. Ramsey,Miguel A. Rodriguez-Bigas,Hans F. A. Vasen,Ernest T. Hawk,J. Carl Barrett,Andrew N. Freedman,Sudhir Srivastava +22 more
TL;DR: This commentary summarizes the Workshop presentations on HNPCC and MSI testing; presents the issues relating to the performance, specificity, and specificity of the Bethesda Guidelines; outlines the revised Bethesda Guidelines for identifying individuals at risk for H NPCC; and recommend criteria for MSI testing.
Journal ArticleDOI
Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999.
Carolyn C. Compton,L. Peter Fielding,Lawrence J. Burgart,Barbara A. Conley,Harry S. Cooper,Stanley R. Hamilton,M. Elizabeth H. Hammond,Donald E. Henson,Robert V. P. Hutter,Raymond B. Nagle,Mary L. Nielsen,Daniel J. Sargent,Clive R. Taylor,Mark L. Welton,Christopher G. Willett +14 more
TL;DR: The current state of knowledge regarding pathologic prognostic factors and predictive factors in colorectal carcinoma was evaluated and recommendations were made to increase the uniformity and completeness of pathologic evaluation of tumor specimens and to improve patient care.
Journal ArticleDOI
Prognostic Factors in Colorectal Cancer
Carolyn C. Compton,Carolyn C. Compton,L. Peter Fielding,Lawrence J. Burgart,Barbara A. Conley,Harry S. Cooper,Stanley R. Hamilton,M. Elizabeth H. Hammond,D. E. Henson,Robert V. P. Hutter,Raymond B. Nagle,Mary L. Nielsen,Daniel J. Sargent,Clive R. Taylor,Mark L. Welton,Christopher G. Willett +15 more
TL;DR: This work states that the current state of knowledge regarding pathologic prognostic factors (factors linked to outcome) and predictive models for disease prediction are inadequate and need to be improved.
Journal ArticleDOI
Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis.
Ariel E. Feldstein,Ali Canbay,Paul Angulo,Makiko Taniai,Lawrence J. Burgart,Keith D. Lindor,Gregory J. Gores +6 more
TL;DR: Hepatocyte apoptosis is significantly increased in patients with NASH and correlates with disease severity, suggesting that antiapoptotic therapy may be useful in this syndrome.
Journal Article
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability
Julie M. Cunningham,Eric R. Christensen,David J. Tester,Cheong Yong Kim,Patrick C. Roche,Lawrence J. Burgart,Stephen N. Thibodeau +6 more
TL;DR: In this article, the methylation status of the presumptive hMLHI promoter region was examined in 31 patients with sporadic colorectal cancer (CRC) and the results suggest that hypermethylation of the hMLH1 promoter may be the principal mechanism of gene inactivation in sporadic CRC characterized by widespread microsatellite instability.