Journal ArticleDOI
Pesticides: an update of human exposure and toxicity.
TLDR
A huge body of evidence exists on the possible role of pesticide exposures in the elevated incidence of human diseases such as cancers, Alzheimer, Parkinson, amyotrophic lateral sclerosis, asthma, bronchitis, infertility, birth defects, attention deficit hyperactivity disorder, autism, diabetes, and obesity.Abstract:
Pesticides are a family of compounds which have brought many benefits to mankind in the agricultural, industrial, and health areas, but their toxicities in both humans and animals have always been a concern. Regardless of acute poisonings which are common for some classes of pesticides like organophosphoruses, the association of chronic and sub-lethal exposure to pesticides with a prevalence of some persistent diseases is going to be a phenomenon to which global attention has been attracted. In this review, incidence of various malignant, neurodegenerative, respiratory, reproductive, developmental, and metabolic diseases in relation to different routes of human exposure to pesticides such as occupational, environmental, residential, parental, maternal, and paternal has been systematically criticized in different categories of pesticide toxicities like carcinogenicity, neurotoxicity, pulmonotoxicity, reproductive toxicity, developmental toxicity, and metabolic toxicity. A huge body of evidence exists on the possible role of pesticide exposures in the elevated incidence of human diseases such as cancers, Alzheimer, Parkinson, amyotrophic lateral sclerosis, asthma, bronchitis, infertility, birth defects, attention deficit hyperactivity disorder, autism, diabetes, and obesity. Most of the disorders are induced by insecticides and herbicides most notably organophosphorus, organochlorines, phenoxyacetic acids, and triazine compounds.read more
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Journal Article
The Canadian Study of Health and Aging
TL;DR: This study confirmed a number of previously reported risk factors for AD, but provided little support for others; a new finding was an increased risk for those with occupational exposure to glues as well as pesticides and fertilizers, but this needs further study.
Journal ArticleDOI
Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate?
TL;DR: Whether damage to such a substrate is the basis for the perceptual differences in olfaction or whether disease-specific or other entities, such as respiratory infections or pollution, are responsible might provide crucial insight into the cause of disease pathology at its earliest stages of development.
The autism spectrum.
TL;DR: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Journal ArticleDOI
A Synaptic Perspective of Fragile X Syndrome and Autism Spectrum Disorders.
TL;DR: It is inferred that there is no single pathway that explains most of the etiology of fragile X syndrome and related ASDs, and new findings and the implications for future work directed at improving the understanding of the pathogenesis and the design of therapeutic strategies to ameliorate these disorders.
Journal ArticleDOI
Ignoring Adjuvant Toxicity Falsifies the Safety Profile of Commercial Pesticides.
Robin Mesnage,Michael Antoniou +1 more
TL;DR: Urgent action is needed to lift the veil on the presence of adjuvant in food and human bodily fluids, as well as in the environment, and to characterize their toxicological properties to protect the environment and general human population from some toxic adjuvants that are currently missing from risk assessments.
References
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Journal ArticleDOI
Rotenone, Paraquat, and Parkinson’s Disease
Caroline M. Tanner,Freya Kamel,G. Webster Ross,Jane A. Hoppin,Samuel M. Goldman,Monica Korell,Connie Marras,Grace S. Bhudhikanok,Meike Kasten,Anabel R. Chade,Kathleen Comyns,Marie Richards,Cheryl Meng,Benjamin Priestley,Hubert H. Fernandez,Franca Cambi,David M. Umbach,Aaron Blair,Dale P. Sandler,J. William Langston +19 more
TL;DR: PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally—those that impair mitochondrial function and those that increase oxidative stress—supporting a role for these mechanisms in PD pathophysiology.
Journal Article
Pesticides and oxidative stress: a review.
TL;DR: It is concluded that stimulation of free radical production, induction of lipid peroxidation, and disturbance of the total antioxidant capability of the body are mechanisms of toxicity in most pesticides, including organophosphates, bipyridyl herbicides and organochlorines.
Journal ArticleDOI
Pesticides and human chronic diseases: evidences, mechanisms, and perspectives.
TL;DR: Genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action are introduced.