Pharmacologic agents released in ultraviolet inflammation studied by continuous skin perfusion
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TLDR
The inflammatory response to ultraviolet radiation (UV) was studied using a skin perfusion method and perfusates from 7 of the 17 subjects studied contained an unidentified smooth muscle-contracting agent, which was not histamine, kinins, serotonin or acetylcholine.About:
This article is published in Journal of Investigative Dermatology.The article was published on 1970-05-01 and is currently open access. It has received 149 citations till now. The article focuses on the topics: Histamine & Kinin.read more
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Journal ArticleDOI
Ultraviolet light induced injury: immunological and inflammatory effects.
TL;DR: An overview of the acute inflammatory and immunological events associated with cutaneous UV exposure is given, which are important to consider before dealing with the complex interactions that occur with chronic UV exposure, leading to photocarcinogenesis.
Journal ArticleDOI
Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation
Timothy J. Williams,J. Morley +1 more
TL;DR: It is concluded that in the guinea pig prostaglandins cannot be regarded as chemical mediators which act directly on the vascular endothelium as do histamine, serotonin (5-hydroxytryptamine) and bradykinin.
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Mechanisms of UV-Induced Inflammation
TL;DR: The inflammation produced by exposure to ultraviolet (UV) light has been well documented clinically and histologically, but the mechanisms by which mediators induce this clinical response remain poorly defined.
Journal ArticleDOI
The human sunburn reaction: Histologic and biochemical studies
TL;DR: Data provide the first evidence that histamine may mediate the early phase of the human sunburn reaction and increase the understanding of its complex histologic and biochemical sequelae.
Journal ArticleDOI
The mode of action of aspirin and similar compounds
TL;DR: Evidence is reviewed which establishes this biochemical action as the basic mode of therapeutic action of aspirin-like drugs as anti-inflammatory, analgesic, and antipyretic compounds, which may also account for the shared side effects.
References
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Journal ArticleDOI
Responses of skin blood vessels to bradykinin, histamine and 5-hydroxytryptamine.
Malcolm W. Greaves,Sam Shuster +1 more
TL;DR: The responses of human cutaneous blood vessels to intradermal injection of bradykinin, histamine and 5‐hydroxytryptamine (serotonin) are studied in order to evaluate the ability of these agents to mediate the vascular changes of sustained acute inflammation in the skin.
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Urticaria pigmentosa and factitious urticaria. Direct evidence for release of histamine and other smooth muscle-contracting agents in dermographic skin.
TL;DR: A method of continuous in vivo subcutaneous perfusion using Tyrode solution which permits direct analysis of pharmacological agents released in inflamed human skin is described and in dermographic skin of patients with urticaria pigmentosa the perfusate was consistently found to contain histamine.
Journal Article
Vascular permeability changes in inflammation. I. The role of endogenous permeability factors in ultraviolet injury.
Greig Logan,D. L. Wilhelm +1 more