Journal ArticleDOI
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia
TLDR
In this paper, a novel mechanism for regulating dopamine activity in subcortical sites and its possible relevance to schizophrenia is proposed, which is based on the regulation of dopamine release into sub cortical regions occurring via two independent mechanisms: (1) transient or phasic dopamine release caused by dopamine neuron firing, and (2) sustained, "background" tonic release regulated by prefrontal cortical afferents.About:
This article is published in Neuroscience.The article was published on 1991-01-01. It has received 1771 citations till now. The article focuses on the topics: Dopamine receptor & Dopamine.read more
Citations
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Book ChapterDOI
Chapter 11 Working memory
TL;DR: This chapter demonstrates the functional importance of dopamine to working memory function in several ways and demonstrates that a network of brain regions, including the prefrontal cortex, is critical for the active maintenance of internal representations.
Journal ArticleDOI
The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
Journal ArticleDOI
Predictive Reward Signal of Dopamine Neurons
TL;DR: Dopamine systems may have two functions, the phasic transmission of reward information and the tonic enabling of postsynaptic neurons.
Journal ArticleDOI
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
TL;DR: It is suggested that dopamine may be more important to incentive salience attributions to the neural representations of reward-related stimuli and is a distinct component of motivation and reward.
Journal ArticleDOI
Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia.
TL;DR: A heuristic framework for linking the psychological and biological in psychosis is provided and it is proposed that a dysregulated, hyperdopaminergic state, at a "brain" level of description and analysis, leads to an aberrant assignment of salience to the elements of one's experience, at an "mind" level.
References
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Handbook of Physiology.
TL;DR: This is the first volume of the proposed many-sectioned "Handbook" in which the American Physiological Society intends to present comprehensively the entire field of physiology.
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Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine
TL;DR: In this relatively brief study, the apparently increased comparative risk of agranulocytosis requires that the use of clozapine be limited to selected treatment-resistant patients.
Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Journal ArticleDOI
Glycine potentiates the NMDA response in cultured mouse brain neurons
J. W. Johnson,P Ascher +1 more
TL;DR: G glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor, and can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.
Book
The Nervous System
TL;DR: The Nervous System as discussed by the authors is a series of intriguing essays ranging over terror, state fetishism, shamanic healing in Latin America, homesickness, and the place of the tactile eye in both magic and modernity.