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PHCOG MAG.: Research Article Antiulcer and antimicrobial activities of Stryphnodendron rotundifolium Mart.
Fabiola Fernandes,Galvão Rodrigues,Henrique Douglas,Melo Coutinho,André Luiz Herzog Cardoso,Adriana Rolim Campos,Galberto Martins da Costa +6 more
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The ethanolic extract of Stryphnodendron rotundifolium stem bark (EESR) was investigated for therapeutic properties using ethanol-induced ulceration in mice and showed antimicrobial activity against five bacterial species but not against the fungi Aspergillus niger.Abstract:
The ethanolic extract of Stryphnodendron rotundifolium stem bark (EESR) was investigated for therapeutic properties using ethanol-induced ulceration in mice. Antimicrobial and preliminary phytochemical screening of the extract was also investigated. The extract (200-400 mg/kg p.o.) dose dependently reduced ethanol (0.2 mL/animal p.o.) - induced ulceration in mice. EESR showed antimicrobial activity against five bacterial species (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Shigella flexineri, Staphylococcus epidermidis) but not against the fungi Aspergillus niger . The above results show that Stryphnodendron rotundifolium bark probably contains some active ingredients that could be developed for health problems as have been claimed by traditional popular use. KEY WORDS. Stryphnodendron rotundifolium ; ethanolic extract; antiulcer; antimicrobial activity. INTRODUCTION Plants are potent biochemists and have been components of phytomedicine since times immemorial (1). The beneficial medicinal effects of plant materials typically result from the combinations of secondary products present in the plant. The medicinal actions of plants are unique to particular plant species or groups are consistent with this concept as the combination of secondary products in a particular plant is taxonomically distinct (2). The genus Stryphnodendron Mart., family Leguminosae, includes about 48 species, all native to central savannas of Brazil, including Stryphnodendron obovatum Benth. (3). The stem bark of several species of Stryphnodendron, which contains about 20% tannins, is used by the local population for wound healing and treatment of leukorrhea and diarrhoea (4). Tannin-rich plants are used in folk medicine because of their antimicrobial properties, and act as scavengers of free radicals (4). Stryphnodendron rotundifoloium (Leguminoseae) popularly know as “Barbatimao” is a typical tree of Cariri Region, Ceara State, Brazil (5). Phytochemical analysis of the ethanol extract of stem bark of “barbatimao” allowed the identification and isolation of tannins and flavonoids. Their barks have been used in folk medicine as cicatrizant and for that reason your biological activity probably can be attributed to the high content of tannins (c.a. 40%) (6,7). In view of the popular use of extracts of Stryphnodendron rotundifoloium, the present study was undertaken to investigate the effect of the ethanolic extract of "barbatimao" stem bark (EESR) on ethanol-induced gastric ulcers and its antimicrobial activity. MATERIAL AND METHODS Plant material. Plant material of S. rotundifolium was collected in September 2005, in line D of the National Forest Araripe, Crato, Ceara State, Brazil. A voucher specimen (# 33621) is deposited at the Herbarium Prisco Bezerra, Universidade Federal do Ceara. Ethanolic bark extract. Dried and powdered stem bark of S. rotundifolium (1.7 Kg) was exhaustively extracted with EtOH at room temperature. The EtOH stem bark extract was dried under reduced pressure to yield (183 g). Animals . Experiments were performed in male Swiss mice (20 – 25 g) obtained from the Central Animal House of this University. They were housed at 22 ± 2read more
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Promising medicinal plants for bioprospection in a Cerrado area of Chapada do Araripe, Northeastern Brazil.
Daiany Alves Ribeiro,Liana Geraldo Souza de Oliveira,Delmacia Gonçalves de Macêdo,Irwin Rose Alencar de Menezes,José Galberto Martins da Costa,Maria Arlene Pessoa da Silva,Sírleis Rodrigues Lacerda,Marta Maria de Almeida Souza +7 more
TL;DR: This study investigated the diversity of medicinal plants in a disjunct area of cerrado in Chapada do Araripe, Ceará, Brazil, and assessed the species of interest for bioprospecting.
Journal ArticleDOI
Fabaceae medicinal flora with therapeutic potential in Savanna areas in the Chapada do Araripe, Northeastern Brazil
Márcia Jordana Ferreira Macêdo,Daiany Alves Ribeiro,Maria de Oliveira Santos,Delmacia Gonçalves de Macêdo,Julimery Gonçalves Ferreira Macedo,Bianca Vilar de Almeida,Manuele E. Saraiva,Maria Natália Soares de Lacerda,Marta Maria de Almeida Souza +8 more
TL;DR: The study evidences that the information of use and/or knowledge are shared among the people within the community, proving the great importance of Fabaceae in the use of medicinal plants.
Journal ArticleDOI
Antioxidant effect of Stryphnodendron rotundifolium Martius extracts from Cariri-Ceará State (Brazil): potential involvement in its therapeutic use.
José Galberto Martins da Costa,Gerlânia de Oliveira Leite,Albys Esther Ferrer Dubois,Rodrigo Lopes Seeger,Aline Augusti Boligon,Margareth Linde Athayde,Adriana Rolim Campos,João Rocha +7 more
TL;DR: The results suggest that S. rotundifolium could be considered an effective agent in the prevention of diseases associated with oxidative stress.
Journal ArticleDOI
Analysis of the Variability of Therapeutic Indications of Medicinal Species in the Northeast of Brazil: Comparative Study.
Julimery Gonçalves Ferreira Macedo,Irwin Rose Alencar de Menezes,Daiany Alves Ribeiro,Maria de Oliveira Santos,Delmacia Gonçalves de Mâcedo,Márcia Jordana Ferreira Macêdo,Bianca Vilar de Almeida,Liana Geraldo Souza de Oliveira,Catarina Pereira Leite,Marta Maria de Almeida Souza +9 more
TL;DR: This study shows the presented divergence in relation to their therapeutic use; in this point, these divergences reinforce the importance of pharmacological research.
Journal ArticleDOI
Antibacterial and modulatory effect of Stryphnodendron rotundifolium.
Dayanne Rakelly de Oliveira,Francisco E. Brito-Junior,Elizângela B. Bento,Edinardo F.F. Matias,Ana Carla A. Sousa,José Galberto Martins da Costa,Henrique Douglas Melo Coutinho,Marta Regina Kerntopf,Irwin Rose Alencar de Menezes +8 more
TL;DR: It is indicated that the extract of S. rotundifolium showed potential synergistic antibiotic activity and proved to be a promising source of antibacterial and modulatory agents.
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