Journal ArticleDOI
Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.
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TLDR
Oral administration of a photoactive drug, 8-methoxypsoralen (methoxsalen), followed by exposure to a high-intensity, longwave ultraviolet-light system resulted in complete clearing of generalized psoriasis in 21 patients.Abstract:
Oral administration of a photoactive drug, 8-methoxypsoralen (methoxsalen), followed by exposure to a high-intensity, longwave ultraviolet-light system resulted in complete clearing of generalized psoriasis in 21 patients. In 16 of these cases, a paired comparison showed methoxsalen followed by longwave ultraviolet light to be more effective than conventional ultraviolet light. 8-Methoxypsoralen followed by exposure to longwave ultraviolet light has previously been shown to inhibit epidermal DNA synthesis; this may be its mechanism of action in psoriasis, a disorder characterized by an accelerated cell cycle and rate of DNA synthesis. The term photochemotherapy is used to emphasize the point that the effect on epidermal proliferation and the therapeutic response require the interaction of light and drug. (N Engl J Med 291:1207–1211, 1974)read more
Citations
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Journal ArticleDOI
The Validity and Practicality of Sun-Reactive Skin Types I Through VI
TL;DR: The concept of sun-reactive "skin typing" was created in 1975 to be able to classify persons with white skin in order to select the correct initial doses of ultraviolet A (UVA) in the application of the then newly developed technique for the treatment of psoriasis—oral methoxsalen photochemotherapy (PUVA).
Journal ArticleDOI
Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results.
Richard L. Edelson,Carole L. Berger,Francis P. Gasparro,Brian V. Jegasothy,Peter Heald,Bruce U. Wintroub,Eric C. Vonderheid,Robert Knobler,K Wolff,G Plewig +9 more
TL;DR: This preliminary study suggests that extracorporeal photochemotherapy is a promising treatment for widespread cutaneous T-cell lymphoma.
Journal ArticleDOI
Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 2. Psoriatic arthritis: Overview and guidelines of care for treatment with an emphasis on the biologics
Alice B. Gottlieb,Neil J. Korman,Kenneth B. Gordon,Steven R. Feldman,Mark Lebwohl,John Koo,Abby S. Van Voorhees,Craig A. Elmets,Craig L. Leonardi,Karl R. Beutner,Reva Bhushan,Alan Menter +11 more
TL;DR: An overview of psoriasis including its cardinal clinical features, pathogenesis, prognosis, classification, assessment tools used to evaluate psoriatic arthritis, and the approach to treatment is given.
Journal ArticleDOI
Influence of a Mindfulness Meditation-Based Stress Reduction Intervention on Rates of Skin Clearing in Patients With Moderate to Severe Psoriasis Undergoing Phototherapy (UVB) and Photochemotherapy (PUVA)
Jon Kabat-Zinn,Elizabeth V. Wheeler,Timothy Light,Anne H. Skillings,Mark J. Scharf,Thomas G. Cropley,David W. Hosmer,Jeffrey D. Bernhard +7 more
TL;DR: A brief mindfulness meditation-based stress reduction intervention delivered by audiotape during ultraviolet light therapy can increase the rate of resolution of psoriatic lesions in patients with psoriasis.
Journal ArticleDOI
Ultraviolet radiation and skin cancer.
TL;DR: In this article, the authors provide a comprehensive overview of skin cancer with an emphasis on carefully evaluated statistics, the epidemiology of UVR-induced skin cancers, incidence rates, risk factors, and preventative behaviors & strategies, including personal behavioral modifications and public educational initiatives.
References
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Book
Carcinogenesis by Ultraviolet Light
TL;DR: In this article, the authors tried to read carcinogenesis by ultraviolet light as one of the reading material to finish quickly and found that reading book can be a great choice when you have no friends and activities to accompany while in your lonely time.
Journal ArticleDOI
Light-induced cross-linking of DNA in the presence of a furocoumarin (psoralen). Studies with phage lambda, Escherichia coli, and mouse leukemia cells.
TL;DR: In this article, it was shown that psoralen cross-links may contribute to the skin photosensitizing action observed for phage λ DNA in vitro and Escherichia coli DNA in intact bacterial cells.
Journal ArticleDOI
Photosensitization of skin in vivo by furocoumarins (psoralens)
Madhu A. Pathak,D.M. Krämer +1 more
TL;DR: During cutaneous photosensitization in vivo, 4,5′,8-trimethylpsoralen undergoes photoaddition with DNA and RNA, which appears to be responsible for epidermal-cell damage.
Journal ArticleDOI
DNA synthesis in normal and xeroderma pigmentosum fibroblasts following treatment with 8-methoxypsoralen and long wave ultraviolet light.
Howard P. Baden,Howard P. Baden,Jennifer M. Parrington,Jennifer M. Parrington,Joy D.A. Delhanty,Joy D.A. Delhanty,Madhu A. Pathak,Madhu A. Pathak +7 more
TL;DR: Study of guinea pig epidermal DNA following treatment of the skin with [ 3 H]trimethylpsoralen and long wave ultraviolet light indicated there is a progressive elimination of the photoadduct.
Journal ArticleDOI
Psoralen Plus Black Light Inhibits Epidermal DNA Synthesis
TL;DR: This study shows that trioxsalen plus black light markedly inhibits epidermal DNA synthesis, and suggests that further critical clinical investigation of psoralens either topically or systemically in combination with black light for proliferative skin diseases is warranted.