Journal ArticleDOI
The Validity and Practicality of Sun-Reactive Skin Types I Through VI
TLDR
The concept of sun-reactive "skin typing" was created in 1975 to be able to classify persons with white skin in order to select the correct initial doses of ultraviolet A (UVA) in the application of the then newly developed technique for the treatment of psoriasis—oral methoxsalen photochemotherapy (PUVA).Abstract:
The concept of sun-reactive "skin typing" was created in 19751for a specific need: to be able to classify personswith white skinin order to select the correct initial doses of ultraviolet A (UVA) (in joules per cubic centimeter) in the application of the then newly developed technique for the treatment of psoriasis—oral methoxsalen photochemotherapy (PUVA).2The need arose as a result of experience with several patients who were a "dark" phenotype (brown or even black hair, and some with brown eyes) but, to our surprise, developed severe phototoxic reactions following oral ingestion of 0.6 mg/kg of methoxsalen and then, two hours later, were exposed to 4 to 6 J/cm2. These initial doses were obviously too high, and it was then understood that the estimation of the white-skinned person's tolerance level to oral PUVA could not be based solely on the phenotype (hair and eye color).read more
Citations
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Journal ArticleDOI
The Protective Role of Melanin Against UV Damage in Human Skin
TL;DR: The major acute and chronic effects of UVR on human skin, the properties of melanin, the regulation of pigmentation and its effect on skin cancer prevention are outlined.
Journal ArticleDOI
Melanocyte biology and skin pigmentation
Jennifer Y. Lin,David E. Fisher +1 more
TL;DR: Pigmentation mutants in various species are highly informative about basic genetic and developmental pathways, and provide important clues to the processes of photoprotection, cancer predisposition and even human evolution.
Journal ArticleDOI
The Role of Vitamin D in Cancer Prevention
Cedric F. Garland,Frank C. Garland,Edward D. Gorham,Martin Lipkin,Harold L. Newmark,Sharif B. Mohr,Michael F. Holick +6 more
TL;DR: The evidence suggests that efforts to improve vitamin D status, for example by vitamin D supplementation, could reduce cancer incidence and mortality at low cost, with few or no adverse effects.
Proceedings ArticleDOI
Model Cards for Model Reporting
Margaret Mitchell,Simone Wu,Andrew Zaldivar,Parker Barnes,Lucy Vasserman,Ben Hutchinson,Elena Spitzer,Inioluwa Deborah Raji,Timnit Gebru +8 more
TL;DR: This work proposes model cards, a framework that can be used to document any trained machine learning model in the application fields of computer vision and natural language processing, and provides cards for two supervised models: One trained to detect smiling faces in images, and one training to detect toxic comments in text.
Journal ArticleDOI
Bio-Integrated Wearable Systems: A Comprehensive Review
Tyler R. Ray,Jungil Choi,Amay J. Bandodkar,Siddharth Krishnan,Philipp Gutruf,Limei Tian,Roozbeh Ghaffari,John A. Rogers +7 more
TL;DR: This review summarizes the latest advances in this emerging field of "bio-integrated" technologies in a comprehensive manner that connects fundamental developments in chemistry, material science, and engineering with sensing technologies that have the potential for widespread deployment and societal benefit in human health care.
References
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Journal ArticleDOI
Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light.
TL;DR: Oral administration of a photoactive drug, 8-methoxypsoralen (methoxsalen), followed by exposure to a high-intensity, longwave ultraviolet-light system resulted in complete clearing of generalized psoriasis in 21 patients.
Journal ArticleDOI
Oral methoxsalen photochemotherapy for the treatment of psoriasis: a cooperative clinical trial
TL;DR: Once a remission was induced, there was no difference in its maintenance when patients were treated once a week, once every other week, or once every third week, and each of these schedules was superior to no maintenance treatment.
Journal ArticleDOI
Unreliability of Self-reported Burning Tendency and Tanning Ability
TL;DR: It is concluded that self-reported burning-tanning histories form an unreliable means of skin typing.