Journal ArticleDOI
Pituitary-Leydig Cell Function in Uremic Males
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TLDR
Although LH was significantly elevated, the elevation was inadequate to promote normal Leydig cell function in most instances, and an impaired pituitary-Leydig cell mechanism was found in association with a normal TBA.Abstract:
Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone and testosterone binding affinity (TBA) were measured in 15 uremic males. The mean control serum testosterone level was 262 ng/100 ml. The testosterone value doubled during acute stimulation with human chorionic gonadotropin (HCG) 4000 U daily, a normal percentage increase. Although LH was significantly elevated, the elevation was inadequate to promote normal Leydig cell function in most instances. This impaired pituitary-Leydig cell mechanism was found in association with a normal TBA. Acute increases in serum testosterone produced by HCG did not alter TBA from control values.read more
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Journal ArticleDOI
The Pituitary-Testicular Axis in Men with Chronic Renal Failure
TL;DR: Chronic renal failure interferes with testicular steroid production and spermatogenesis, and the effects of uremia on the pituitary-testicular axis in 35 men with creatinine clearances less than 4 ml per minute per 1.7m was studied.
Journal ArticleDOI
Ovarian Function in Chronic Renal Failure: Evidence Suggesting Hypothalamic Anovulation
TL;DR: In uremic women, the continued secretion of estrogen, the rise of plasma levels of luteinizing hormone, FSH, and estradiol after clomiphene, and the elevated gonadotropin levels during menopause suggest that the negativeEstradiol feedback, the tonic gonadotropic secretion, andThe pituitary ovarian axis were normal.
Journal ArticleDOI
Gonadal dysfunction in uremic men. A study of the hypothalamo-pituitary-testicular axis before and after renal transplantation.
Victoria S. Lim,Victor S. Fang +1 more
TL;DR: It is postulated that a defect in that portion of the hypothalamus involved in the receipt and/or interpretation of message might be at fault in uremia.
Journal ArticleDOI
Reversal of uræmic impotence by zinc
TL;DR: In eight impotent haemodialysed men with low plasma-zinc levels sexual function, including potency, frequency of intercourse, libido, and plasma testosterone, was determined before and after therapy with zinc or placebo.
Journal ArticleDOI
Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study.
Sudesh K. Mahajan,Ali A. Abbasi,Ananda S. Prasad,Parviz Rabbani,William A. Briggs,Franklin D. McDonald +5 more
TL;DR: It is suggested that zinc deficiency is a reversible cause of gonadal dysfunction in patients having regular hemodialysis and patients receiving zinc had an improvement in potency, libido, and frequency of intercourse not found in the placebo group.
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