Journal ArticleDOI
Placebo-controlled trial of terlipressin (glypressin) in the management of acute variceal bleeding.
TLDR
In a double-blind trial 60% of acute variceal bleeding episodes were controlled with terlipressin (glypressin) compared with 37% in patients given placebo (NS).Abstract:
In a double-blind trial 60% of acute variceal bleeding episodes were controlled with terlipressin (glypressin) compared with 37% in patients given placebo (NS). Rebleeding was more common in the placebo group so that at 5 days bleeding remained under control in 54% of patients treated with terlipressin compared with only 19% after placebo therapy (p less than 0.025). Blood transfusion requirements were similar in the two groups. Terlipressin appeared to be the most effective in those patients with severe hepatic dysfunction.read more
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Journal ArticleDOI
The treatment of portal hypertension: A meta-analytic review
Journal ArticleDOI
UK guidelines on the management of variceal haemorrhage in cirrhotic patients
Dhiraj Tripathi,Adrian J. Stanley,Peter C. Hayes,David Patch,Charles Millson,Homoyon Mehrzad,Andrew Austin,James Ferguson,Simon Olliff,Mark Hudson,John M. Christie +10 more
TL;DR: These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG.
Journal ArticleDOI
Natural history of portal hypertension in patients with cirrhosis.
TL;DR: All patients with cirrhosis will eventually develop portal hypertension and esophagogastric varices, and patients surviving a variceal hemorrhage must be treated to prevent rebleeding.
Journal ArticleDOI
Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients
TL;DR: Early administration of terlipressin combined with glyceryl trinitrate (TER-GTN) lowers the deleterious consequences of prolonged hypovolaemia on the hepatic function of these patients.
Journal ArticleDOI
Terlipressin for acute esophageal variceal hemorrhage
TL;DR: The meta-analysis indicates that terlipressin was associated with a statistically significant reduction in all cause mortality compared to placebo, and might be the vasoactive agent of choice in acute variceal bleeding.