Open Access
Plasma xanthine levels inlowbirthweight infants treated ornottreated withtheophylline
Hubert Renaud,Bruno Ribon +1 more
TLDR
Clear conclusions are led on the optimum timing and dosage of theophylline, and on the need to monitor plasma levels of both theophyelline and caffeine in newborn infants treated with theophyLLine.About:
The article was published on 1979-01-01 and is currently open access. It has received 44 citations till now. The article focuses on the topics: Xanthine.read more
Citations
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Journal ArticleDOI
The Health Consequences of Caffeine
TL;DR: Caffeine does not appear to be useful for increasing the motility of hypomotile sperm in artificial insemination or in the therapy of minimal brain dysfunction, cancer, or Parkinson's syndrome, but it may be effective as a topical treatment of atopic dermatitis and as systemic therapy for neonatal apnea.
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Principles of Drug Biodisposition in the Neonate
James B. Besunder,James B. Besunder,Michael D. Reed,Michael D. Reed,Jeffrey L. Blumer,Jeffrey L. Blumer +5 more
TL;DR: Recommendations for neonatal drug therapy are based upon a critical interpretation of data, an understanding of fetal development and maturational processes, and anUnderstanding of how disease states may affect drug biodisposition in the neonate.
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Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part II)
TL;DR: Recommendations for neonatal drug therapy are based upon a critical interpretation of data, an understanding of fetal development and maturational processes, and a understanding of how disease states may affect drug biodisposition in the neonate.
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In vivo age-related changes in hepatic drug-oxidizing capacity in humans
TL;DR: The purpose of this study is to review the literature on the changes in probe‐drug metabolism, classified by cytochrome P450 (P450 or CYP) at five stages in life: neonates < 4 weeks, infants < 12 months, children < 19 years, young/mature adults 20–64 years, and elderly adults >65 years.
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Methylxanthines: toxicity to humans. 2. Caffeine.
TL;DR: The use, effects and toxicity of caffeine intake are reviewed separately for different segments of the population and controversy concerning the possible association of caffeine with fibrocystic disease of the breast and over the behavioural effects of the drug is presented briefly.
References
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Journal ArticleDOI
Clinical assessment of gestational age in the newborn infant
TL;DR: A scoring system for gestational age, based on 10 neurologic and 11 “external” criteria, has been applied to 167 newborn infants and gives consistent results within the first 5 days and is equally reliable in the first 24 hours of life.
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Pharmacokinetic Aspects of Theophylline in Premature Newborns
TL;DR: To characterize further the pharmacokinetics of theophylline in premature infants, its concentraion in blood was measured by high-pressure liquid chromatography after intravenous infusion given to six apneic premature newborns three to 15 days of age.
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Efficacy of caffeine in treatment of apnea in the low-birth-weight infant.
Jacob V. Aranda,Jacob V. Aranda,Winifred Gorman,Winifred Gorman,Hardur Bergsteinsson,Hardur Bergsteinsson,Tania Gunn,Tania Gunn +7 more
TL;DR: Caffeine is an effective pharmacologic respirogenic agent in the preterm infant with apnea and all infants except one showed a significant decrease in the frequency of apneic episodes associated with caffeine therapy.
Journal Article
Apnea in premature infants: monitoring, incidence, heart rate changes, and an effect of environmental temperature
TL;DR: Continuous monitoring of respiration in small infants is now clinically feasible suggesting that early intervention is required to prevent significant hypoxia and central depression from apnea.
Journal Article
Prevention of apnea and bradycardia in low-birthweight infants.
TL;DR: Theophylline in six hourly oral doses yielded two-hour serum concentrations of 6.6 to 11.0 mug/ml which completely controlled apneic spells exceeding 20 seconds in duration and markedly reduced 10- 19-second apneIC episodes and any resultant bradycardia.