Journal ArticleDOI
Plasmodium Falciparum Malaria and Human Red Cells. II. Red Cell Genetic Traits and Resistance Against Malaria
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TLDR
The results suggest that Hb AS as well as the female genotype GdA-/GdB offer selective advantage against the disease.Abstract:
In 702 Nigerian children under 6 years of age the incidence and the severity of malarial infection was studied with respect to haemoglobin types and red cell glucose-6-phosphate dehydrogenase variants. The results suggest that Hb AS as well as the female genotype GdA-/GdB offer selective advantage against the disease. Parasite densities in carriers of these genotypes were significantly lower than in other subjects. Whereas protection by Hb AS was found mainly in children between 2 and 4 years of age, the advantage afforded by GdA-/GdB was similar in all age groups. Possible mechanisms are discussed.read more
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Journal ArticleDOI
Glucose-6-phosphate dehydrogenase deficiency
Cappellini,Gemino Fiorelli +1 more
TL;DR: The most effective management of G6PD deficiency is to prevent haemolysis by avoiding oxidative stress, and Screening programmes for the disorder are undertaken, depending on the prevalence of G 6PD deficiency in a particular community.
Journal ArticleDOI
World Distribution, Population Genetics, and Health Burden of the Hemoglobinopathies
TL;DR: The inherited hemoglobin disorders are a reflection of natural selection combined with a high frequency of consanguineous marriages in many countries, together with an epidemiological transition; whereby, as public health measures improve in the poorer countries of the world, more babies are surviving to present for treatment.
Journal ArticleDOI
Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis
TL;DR: Haemoglobin AS, CC, and AC genotypes and homozygous and heterozygous α-thalassaemia provide significant protection from severe malaria syndromes, but these haemoglobinopathies differ substantially in the degree of protection provided and confer mild or no protection against uncomplicated malaria and asymptomatic parasitaemia.
Journal ArticleDOI
An Immune Basis for Malaria Protection by the Sickle Cell Trait
Thomas N. Williams,Tabitha W. Mwangi,David J. Roberts,Neal Alexander,David J. Weatherall,Sammy Wambua,Moses Kortok,Robert W. Snow,Robert W. Snow,Kevin Marsh,Kevin Marsh +10 more
TL;DR: Analysis of the age-specific protection afforded by HbAS against clinical malaria in children living on the coast of Kenya found that protection increased with age from only 20% in the first 2 y of life to a maximum of 56% by the age of 10 y, returning thereafter to 30% in participants greater than 10 y old.
Journal Article
World distribution, population genetics, and health burden of the hemoglobinopathies
TL;DR: In this paper, the inherited hemoglobin disorders pose an increasing burden on global health resources in the future, due to natural selection combined with a high frequency of consanguineous marriages in many countries, together with an epidemiological transition.