Journal ArticleDOI
Glucose-6-phosphate dehydrogenase deficiency
Cappellini,Gemino Fiorelli +1 more
TLDR
The most effective management of G6PD deficiency is to prevent haemolysis by avoiding oxidative stress, and Screening programmes for the disorder are undertaken, depending on the prevalence of G 6PD deficiency in a particular community.About:
This article is published in The Lancet.The article was published on 2008-01-05. It has received 1308 citations till now. The article focuses on the topics: Glucosephosphate Dehydrogenase Deficiency & Haemolysis.read more
Citations
More filters
Journal Article
Glucose-6-phosphate dehydrogenase deficiency.
I Siswadi,H Notopuro,S Untario +2 more
TL;DR: A defect in an enzyme called glucose-6-phosphate dehydrogenase causes red blood cells to break down prematurely, which results in the destruction ofRed blood cells, which carry oxygen from the lungs to tissues throughout the body.
Journal ArticleDOI
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Anna Stincone,Alessandro Prigione,Thorsten Cramer,Mirjam M.C. Wamelink,Kate Campbell,Eric Cheung,Viridiana Olin-Sandoval,Nana-Maria Grüning,Antje Krüger,Mohammad Tauqeer Alam,Markus A. Keller,Michael Breitenbach,Kevin M. Brindle,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser +15 more
TL;DR: The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism as discussed by the authors, which shares reactions with the Entner-Doudoroff pathway and the Calvin cycle and divides into an oxidative and non-oxidative branch.
Journal ArticleDOI
Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions
TL;DR: It is concluded that the intriguingly complex regulation and function of mammalian thioredoxin reductases within the cellular context and in intact mammals strongly suggests that their functions are highly fi ne-tuned with the many pathways involvingThioredoxins and thiOREDoxin-related proteins.
Journal ArticleDOI
Artemisinin resistance: current status and scenarios for containment
Arjen M. Dondorp,Arjen M. Dondorp,Shunmay Yeung,Shunmay Yeung,Lisa J. White,Lisa J. White,Chea Nguon,Nicholas P. J. Day,Nicholas P. J. Day,Duong Socheat,Lorenz von Seidlein +10 more
TL;DR: A multifaceted containment programme has recently been launched, including early diagnosis and appropriate treatment, decreasing drug pressure, optimising vector control, targeting the mobile population, strengthening management and surveillance systems, and operational research.
References
More filters
Book
The Metabolic and Molecular Bases of Inherited Disease
TL;DR: In this paper, the authors present a list of disorders of MITOCHONDRIAL FUNCTION, including the following: DISORDERS OF MIOCHONDRIC FERTILITY XIX, XVI, XIX.
Journal ArticleDOI
Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation
TL;DR: These guidelines provide a framework for the prevention and management of hyperbilirubinemia in newborn infants of 35 or more weeks of gestation and recommend that clinicians promote and support successful breastfeeding and treat newborns with phototherapy or exchange transfusion to prevent the development of severe hyperbil Kirubin encephalopathy.
Book
History of Western Philosophy
TL;DR: The History of Western Philosophy (HOWP) as mentioned in this paper is one of the most popular philosophy books of the 20th century and is the most important philosophical work of all time.
Book ChapterDOI
Glucose-6-phosphate Dehydrogenase
TL;DR: G6P-DH is inhibited by primaquine and other 8-aminoquinolines (antimalarial drugs) in millimolar concentration, as well as by phenylhydrazine, Nevertheless, the therapeutic concentration of these substances is more than tenfold lower and therefore, they have no significant effect on the measurements.