Patent
Polyaryl antitumor agents
Ching Te Chang,Yuh-Lin Yang +1 more
TLDR
A compound of the formula: Ar.sub.1 -B--Ar.sub-2 where Ar 1 is unsubstituted or substituted phenyl, thienyl, furanyl, or pyrrolyl, in which each substituent of the substituted persons, such as phenyl and pyrronyl, independently, is aldehyde, acyl, ester, carboxyl, amido, nitrile, nitro, cyano, acetal, oxoalkyl, aminoalkyl and oxo-alkyl as discussed by the authors.Abstract:
A compound of the formula: Ar.sub.1 --B--Ar.sub.2 wherein Ar 1 is unsubstituted or substituted phenyl, thienyl, furanyl, or pyrrolyl, in which each substituent of the substituted phenyl, substituted thienyl, substituted furanyl, and substituted pyrrolyl, independently, is aldehyde, acyl, ester, carboxyl, amido, nitrile, nitro, cyano, acetal, ketal, oxoalkyl, aminoalkyl, hydroxyalkyl, haloalkyl, iminoalkyl, acid halide, aminoalkylaminoalkyl, aminoalkylaminoalkylamino, hydroxyalkylaminoalkyl, or hydroxyalkylaminoalkylaminoalkyl; B is, --CH═CH--, or --C C--, in which R is H, alkyl, hydroxyl, alkoxy, ester, aldehyde, hydroxyalkyl, aminoalkyl, carboxyl, --CH(OR 1 ) 2 , or NR 2 R 3 , where each R 1 , independently, is H, alkyl, or acyl; and each of R 2 and R 3 , independently, is H, alkyl, hydroxyalkyl, or aminoalkyl; and Ar 2 is substituted phenyl, substituted thienyl, substituted furanyl, or substituted pyrrolyl, in which each substituent of the substituted phenyl, substituted thienyl, substituted furanyl, and substituted pyrrolyl, independently, is amido, nitrile, nitro, cyano, acetal, ketal, oxoalkyl, aminoalkyl, haloalkyl, iminoalkyl, acid halide, aminoalkylaminoalkyl, aminoalkylaminoalkylamino, hydroxyalkylaminoalkyl, or hydroxyalkylaminoalkylaminoalkyl; or a salt thereof. Also disclosed is a composition which contains a pharmaceutical acceptable carrier and an effective amount of a compound of the above formula.read more
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Patent
Mediators of hedgehog signaling pathways, compositions and uses related thereto
TL;DR: In this paper, the authors present methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain of function, ptc loss of function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to induce an abnormal growth state.
Patent
Novel thiophene derivatives, preparation method thereof and pharmaceutical compositions containing same
Anne-Claude Dublanchet,Delphine Compere,Philippe Cluzeau,Stephane Blais,Alexis Denis,Pierre Ducrot,Karine Courte,Sophie Descamps +7 more
TL;DR: In this article, the authors define caracterises en ce que.bullet, i.e., oxygene ou soufre,.Bullet, and X represent oxygenes, NH ou -N(C1-C6)alkyle,, and Y represent pyridyle, aryle, cycloalkenyle.
References
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Journal ArticleDOI
Model reactions on roast aroma formation. XIII. The formation of some uncommon N-heterocyclic compounds and furans after roasting of tryptophan with reducing sugars and sugar degradation products
Werner Baltes,Eberhard Knoch +1 more
TL;DR: In this paper, after treatment of d -glucose and d -xylose with tryptophan under the conditions of coffee roasting, 311 volatile compounds were identified.
Journal ArticleDOI
Electrochemical synthesis and optical analysis of poly[(2,2′-dithienyl)-5,5′-diylvinylene]
Maria Martinez,John R. Reynolds,Sanjay Basak,Douglas A. Black,Dennis S. Marynick,Martin Pomerantz +5 more
TL;DR: The electrochemical synthesis of poly[2,2′-dithienyl)-5,5′-diylvinylene tetrafluoroborate] (PDTE/BF4) has been accomplished and provides coppery-black free-standing films with a room-temperature four-probe conductivity as high as 15 (Ω cm)−1.
Journal Article
Ultraviolet-mediated antibiotic activity of synthetic thiophenes and their acetylenic derivatives
James B. Hudson,G. H. N. Towers,Z. Abramowski,L. L. Hudson,Renzo Rossi,Adriano Carpita,Dario Neri +6 more
Journal ArticleDOI
Electrochemical preparation of poly(di(2-thienyl) benzene)s and poly(4,4'-di(2-thienyl) biphenyl)
TL;DR: In this article, the infrared spectra of the films indicated oxidative coupling to occur at the 5 and 5′ positions of the thiophene rings in T13B, T14B and TBP.
Patent
Medicinal thiophene compounds
TL;DR: A method of treating inflammation including administering to a subject an effective amount of a compound of the following formula: ##STR1## wherein m is 1-4; and each of A and B, independently, is H, C 1-7 alkyl, C 2-7 alkynyl, (CH 2 ) n CHO, CH 2 ) o COOH, c 1- 7 alkoxy, c 2 -7 alkoxyalkyl, CN, NO 2, halogen, CH(OR 1 ) 2, CO.CR 4, CR 1 =CR 5 R