Poor glycemic control is associated with the risk of subclinical hypothyroidism in patients with type 2 diabetes mellitus.
Jae Ho Cho,Ho Jin Kim,Jun Ho Lee,Il Rae Park,Jun Sung Moon,Ji Sung Yoon,Inkyu Lee,Kyu Chang Won,Hyoung Woo Lee +8 more
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Poor glycemic control in T2DM was obviously associated with the risk of SCH, especially in elderly women with poor gly glucose control, and the results suggest SCH as comorbidity may be considered in elderlyWomen with poorglycemic control.Abstract:
BACKGROUND/AIMS Overt hypothyroidism is frequently found in patients with type 2 diabetes mellitus (T2DM), but it remains unknown the relationship between subclinical hypothyroidism (SCH) and T2DM. We attempt to evaluate the difference in prevalence of SCH between patients with T2DM and general population, and the association between SCH and glycemic control status ofdiabetic patients. METHODS This was cross-sectional study. Total 8,528 subjects who visited for health check-up were recruited. SCH was defined as an elevated level of serum thyroid stimulating hormone (> 4.0 mIU/L) with a normal level of free thyroxine. T2DM group was categorized into three groups by glycosylated hemoglobin (HbA1c): < 7% (reference), ≥ 7% and < 9%, ≥ 9%. RESULTS Finally, 7,966 subjects were included. The prevalence of SCH was not different between healthy controls and subjects with T2DM (8.1% vs. 7.4%, p = 0.533; in men, 5.7% vs. 5.1%, p = 0.573; in women, 10.9% vs. 11.7%, p = 0.712), but it was increased with highest HbA1c group more than well controlled group, especially in women. The risk of SCH was increased by group with poorer glycemic control; the odds ratio for HbA1c ≥ 9% compared to < 7% was 2.52 (95% confidence interval [CI], 1.09 to 5.86; p = 0.031), and 4.58 (95% CI, 1.41 to 14.87; p = 0.011) in women, but not significant in men. CONCLUSIONS The prevalence of SCH was similar between T2DM and healthy group. Poor glycemic control in T2DM was obviously associated with the risk of SCH, especially in elderly women. These results suggest SCH as comorbidity may be considered in elderly women with poor glycemic control.read more
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Standards of Medical Care in Diabetes
TL;DR: These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, treatment goals, and tools to evaluate the quality of care.
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Thyroid hormones and diabetic nephropathy: An essential relationship to recognize
Qianqian Han,Junlin Zhang,Yiting Wang,Hanyu Li,Rui Zhang,Ruikun Guo,Li Li,Geer Teng,Jiali Wang,Tingli Wang,Fang Liu +10 more
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Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus.
T I De Vries,L. J. Kappelle,Y. van der Graaf,H. W. de Valk,G.J. de Borst,Hendrik M. Nathoe,Frank L.J. Visseren,Jan Westerink +7 more
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Sex-influenced association between free triiodothyronine levels and poor glycemic control in euthyroid patients with type 2 diabetes mellitus.
Tianyue Zhang,Juan Shi,Ying Peng,Shujie Wang,Qian Mu,Qianhua Fang,Weiqiong Gu,Jie Hong,Yifei Zhang,Weiqing Wang +9 more
TL;DR: FT3 in the reference range was significantly associated with reduced risk of HbA1c ≥ 8% in males, independent of traditional risk factors for poor glycemic control.
References
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Standards of Medical Care in Diabetes
TL;DR: These standards of care are intended to provide clinicians, patients, researchers, payors, and other interested individuals with the components of diabetes care, treatment goals, and tools to evaluate the quality of care.
Journal ArticleDOI
Standards of medical care in diabetes.
TL;DR: I would like to take issue with the use of the phrase “standards of medical care in diabetes,” which is used to describe diabetes care standards, in the recently updated and circulatedADA 2006 Clinical Practice Recommendations.
Journal ArticleDOI
Serum TSH, T4, and Thyroid Antibodies in the United States Population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)
Joseph G. Hollowell,Norman W. Staehling,W. Dana Flanders,W. Harry Hannon,Elaine W. Gunter,Carole A. Spencer,Lewis E. Braverman +6 more
TL;DR: TSH and the prevalence of antithyroid antibodies are greater in females, increase with age, and are more in whites and Mexican Americans than in blacks, which needs more research to relate these findings to clinical status.
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The Colorado Thyroid Disease Prevalence Study
TL;DR: The results confirm that thyroid dysfunction is common, may often go undetected, and may be associated with adverse health outcomes that can be avoided by serum TSH measurement.
Journal ArticleDOI
Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study
TL;DR: This population-based study examined whether subclinical hypothyroidism and thyroid autoimmunity are associated with aortic atherosclerosis and myocardial infarction in elderly women who were participating in the Rotterdam Study.