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Post morten changes and regional distribution of substance P in the rat and mouse nervous system
Ichiro Kanazawa,T. Jessell +1 more
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This article is published in Brain Research.The article was published on 1976-11-26. It has received 301 citations till now.read more
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Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals
TL;DR: It was difficult to identify substance-P immunoreactive axons in the rats studied, and further experimental studies are necessary to elucidate the projections of the substance P-immunoreactive neurons in the rat central nervous system.
Journal ArticleDOI
Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding
TL;DR: Specific [3H]diazepam binding to membranes appears to be restricted to brain, where it is unevenly distributed: the density of diazepam receptors is about five times higher in cortex (the highest density) than in pons-meddula (lowest density).
Journal ArticleDOI
Opiate analgesics inhibit substance P release from rat trigeminal nucleus.
T. M. Jessell,L. L. Iversen +1 more
TL;DR: It is reported here that opiate analgesics are able to suppress the stimulus-evoked release of SP, which may represent a mechanism for the direct spinal analgesic actions of opiates.
Journal ArticleDOI
Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system.
Tomas Hökfelt,Tomas Hökfelt,Åke Ljungdahl,Åke Ljungdahl,Harry W.M. Steinbusch,Harry W.M. Steinbusch,A. Verhofstad,A. Verhofstad,G. Nilsson,G. Nilsson,E. Brodin,E. Brodin,B. Pernow,B. Pernow,Menek Goldstein +14 more
TL;DR: Findings indicate that substance P and 5-HT may coexist not only in some cell bodies but also in axons and nerve endings in neurons of the lower medulla oblongata.
Journal ArticleDOI
The distribution of substance P immunoreactive fibers in the rat central nervous system
TL;DR: The hypothesis that substance P may be a widespread neurotransmitter in the central nervous system is supported by results obtained by applying an indirect immunofluorescent technique.
References
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Journal ArticleDOI
Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain.
TL;DR: It is revealed that norepinephrine and dopamine are specifically localized in complex systems of neurons in the brain, a finding which lends support to the hypothesis that both amines may be neurotransmitters in the central nervous system.
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Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons.
TL;DR: The present results give strong evidence for the occurrence of SP in a certain population of primary sensory neurons and support earlier findings that SP may act as a transmitter or modulator in these neurons.
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Amino-acid Sequence of Substance P
TL;DR: The initial studies were made on crude acid alcohol extracts of equine brain and intestine, dried in powder form, and the active principle in the preparation was later referred to as substance P (P for powder), and this non-committal term subsequently achieved widespread acceptance in the literature, in the absence of any clearly definable biological role.
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Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P
Michael M. Chang,Susan E. Leeman +1 more
TL;DR: Biological testing showed that the sialogogic peptide isolated is indistinguishable from Substance P, and it stimulates contraction of the guinea pig ileum and the rat duodenum and is a potent vasodepressor.
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Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section.
TL;DR: The results suggest that hypothalamic substance P synthesized in the spinal ganglia is transported in the dorsal root toward their intraspinal axon terminals, where the substance is concentrated and serves as a neurotransmitter.