Potassium-depolarization induces motility in isolated outer hair cells by an osmotic mechanism
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TLDR
The results strongly suggest that K+ induces shape changes of outer hair cells via osmotic forces and that intracellular calcium mediates contractions by a different mechanism.About:
This article is published in Hearing Research.The article was published on 1988-02-01 and is currently open access. It has received 85 citations till now. The article focuses on the topics: Calcium & Osmotic concentration.read more
Citations
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Journal ArticleDOI
Phantom auditory perception (tinnitus): mechanisms of generation and perception
TL;DR: Existing theories and their extrapolation are presented, together with some new potential mechanisms of tinnitus generation, encompassing the involvement of calcium and calcium channels in cochlear function, with implications for malfunction and aging of the auditory and vestibular systems.
Journal ArticleDOI
Cochlear Outer Hair Cell Motility
TL;DR: The functional and structural properties of prestin are described and whether outer hair cell motility might account for sound amplification at all frequencies is also a critical question and is reviewed here.
Journal ArticleDOI
Structural features of the lateral walls in mammalian cochlear outer hair cells.
TL;DR: Freeze-fracture, freeze-etching and thin sections have been used to determine features of the structural organisation of the lateral walls in cochlear outer hair cells and the lateral plasma membrane is shown to be protein-rich and to contain cholesterol.
Journal ArticleDOI
Aminoglycoside antibiotics impair calcium entry but not viability and motility in isolated cochlear outer hair cells.
TL;DR: These cells, isolated from the guinea pig cochlea and maintained in short‐term culture, were used as a model for evaluating the acute effects of gentamicin on cell viability, depolarization‐induced transmembrane calcium flux, and depolarized‐induced motile responses.
Book ChapterDOI
Outer Hair Cell Motility
TL;DR: Outer hair cells (OHCs) are extremely versatile mechanical components of the cochlea and may receive additional information from mechanoreceptive elements in their basolateral membrane.
References
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Journal ArticleDOI
Evoked mechanical responses of isolated cochlear outer hair cells
TL;DR: The microarchitecture of the organ of Corti permits length changes of outer hair cells in a manner that could significantly influence the mechanics of the cochlear partition and thereby contribute to the exquisite sensitivity of mammalian hearing.
Journal ArticleDOI
Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle
TL;DR: In a wide variety of excitable cells the transmembrane exchange of the monovalent marine cations Na and K can be considered the substantial basis of bioelectric membrane activity, whereas Ca ions are required as mediators when, by this superfi cial process, intracellular reactions such as muscular contraction, glandular secre tion, or liberation of transmitter substances are initiated.
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A fast motile response in guinea-pig outer hair cells: the cellular basis of the cochlear amplifier.
TL;DR: Outer hair cells from the cochlea of the guinea‐pig were isolated and their motile properties studied in short‐term culture by the whole‐cell variant of the patch recording technique, concluding that interaction between actin and myosin, although present in the cell, is unlikely to account for the cell motility.
Journal ArticleDOI
A model for active elements in cochlear biomechanics
Stephen T. Neely,Duck O. Kim +1 more
TL;DR: A linear, mathematical model of cochlear biomechanics is presented and active elements are intended to represent the motile action of outer hair cells to simulating the high sensitivity and sharp tuning characteristic of the mammalian cochlea.
Journal ArticleDOI
Electrokinetic shape changes of cochlear outer hair cells
TL;DR: Elect electrically evoked mechanical changes in isolated cochlear outer hair cells (OHCs) are described with characteristics which suggest that direct electrokinetic phenomena are implicated in the response.