Journal ArticleDOI
Prematurity and perinatal mortality in pregnancies complicated by maternal Chlamydia trachomatis infections.
David H. Martin,Laura A. Koutsky,David A. Eschenbach,Janet R. Daling,E. Russell Alexander,Jacqueline Benedetti,King K. Holmes +6 more
TLDR
Infected women were significantly younger than noninfected women, and significantly more often unmarried, supported by public assistance, and pregnant for the first time, among women followed up from 19 weeks' gestation until delivery, the mean duration of gestation was significantly shorter for those with antepartum chlamydial infection.Abstract:
In a prospective study of morbidity associated with Chlamydia trachomatis infections during pregnancy, we isolated C trachomatis from the endocervix of 18 (6.7%) of 268 women examined before 19 weeks' gestation. Infected women were significantly younger than noninfected women, and significantly more often unmarried, supported by public assistance, and pregnant for the first time. Among women followed up from 19 weeks' gestation until delivery, the mean duration of gestation was significantly shorter for those with antepartum chlamydial infection. Stillbirth or neonatal death occurred in six (33%) of the 18 pregnancies of infected women compared with eight (3.4%) of the 238 pregnancies of noninfected women followed up from the 19th week of gestation through delivery. Stillbirth or neonatal death occurred ten times more often among Chlamydia infected women than among uninfected controls matched for age, marital status, socioeconomic status, pregnancy order, and race. ( JAMA 1982;247:1585-1588)read more
Citations
More filters
Journal ArticleDOI
A review of premature birth and subclinical infection
TL;DR: Results support the hypothesis that premature birth results in part from infection caused by genital tract bacteria, and research efforts must be prioritized to determine the role of infection and the appropriate prevention of this cause of prematurity.
Journal ArticleDOI
Independent associations of bacterial vaginosis and Chlamydia trachomatis infection with adverse pregnancy outcome.
Michael G. Gravett,H. Preston Nelson,Timothy A. DeRouen,Cathy W. Critchlow,David A. Eschenbach,King K. Holmes +5 more
TL;DR: Pregnancy outcome to bacterial vaginosis, an anaerobic vaginal condition, and to other selected genital pathogens among 534 gravid women was prospectively studied, finding that neonates born to women with bacterialvaginosis had lower mean birth weight than did neonatesBorn to women without bacterial vagInosis.
Journal ArticleDOI
Current methods of laboratory diagnosis of Chlamydia trachomatis infections.
TL;DR: The diagnostic methods for C. trachomatis infection that are currently approved for use in the United States are described and compared, including the newest DNA amplification technologies which are yet to be licensed for commercial use.
Journal ArticleDOI
Chlamydia trachomatis: impact on human reproduction
Jorma Paavonen,W Eggert-Kruse +1 more
TL;DR: The development of highly sensitive and specific nucleic acid amplification tests for the diagnosis of chlamydial infections has been an important advance in the ability to conduct population-based screening programmes to prevent complications.
Journal ArticleDOI
Risk factors for prematurity and premature rupture of membranes: a prospective study of the vaginal flora in pregnancy.
Howard Minkoff,Amos Grunebaum,Richard H. Schwarz,Joseph Feldman,Marinella Cummings,William R. Crombleholme,Lorraine Clark,George F. Pringle,William M. McCormack +8 more
TL;DR: It is concluded that microbiologic screening in early pregnancy may aid in the assessment of patient risk for preterm delivery and the presence of various vaginal pathogens in earlyregnancy was associated with the subsequent development of premature rupture of membranes or preterm labor.
References
More filters
Journal ArticleDOI
Causes and consequences of premature rupture of fetal membranes
R. L. Naeye,EllenC. Peters +1 more
TL;DR: There was no relation between the frequency of premature rupture and the number of coital acts in the month before delivery but at every gestational age the proportion of fetuses and neonates who died with amniotic-fluid infections was greater when coitus had occurred in the week before delivery.
Journal ArticleDOI
The risk of low birthweight.
TL;DR: Descriptive analyses of birthweight for single live births in the United States during 1974, using birth certificate information, show that several factors are associated with a high incidence of low birthweight babies.
Journal ArticleDOI
Are Chlamydial Infections the Most Prevalent Venereal Disease
Julius Schachter,Lavelle Hanna,Edward C. Hill,Susan Massad,Charles W. Sheppard,John E. Conte,Stephen N. Cohen,Karl F. Meyer +7 more
TL;DR: In both population groups, chlamydiae were more prevalent than herpesviruses, and chlamydial infection was associated much more commonly with cervicitis than with vaginitis only.
Journal ArticleDOI
Birth Weight and Genital Mycoplasmas in Pregnancy
Peter Braun,Yhu-Hsiung Lee,Jerome O. Klein,S M Marcy,T A Klein,D Charles,P Levy,Edward H. Kass +7 more
TL;DR: The presence of T-strains in the urine and cervix was independent of other risk factors for low birth weight and was not related to shortened gestational length.
Journal ArticleDOI
Isolation of Chlamydia trachomatis by Use of 5-Iodo-2-Deoxyuridine—Treated Cells
TL;DR: Data indicate that IUDR treatment of cells is at least equally effective for the isolation of C. trachomatis, and stock chlamydial strains gave similar titers of iodine-stained inclusions in either system.