Prevention of recurrences in frequently relapsing herpes labialis with thymopentin a randomized double-blind placebo-controlled multicenter study
K. Bolla,D. Djawari,E.M. Kokoschka,J. Petres,S. Liden,Gonseth R,Amblard P,Bernengo Mg,Bonerandi Jj,Claudy A +9 more
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TLDR
The results achieved with thymopentin for the individual parameters were significantly superior to those obtained with placebo; thus significant improvement was seen in patients on Thymopentine in the duration of the longest symptomfree period.Abstract:
The present randomized, placebo-controlled double-blind multicenter study included a population of 36 subjects with frequent recurrences (at least once a month) of herpes labialis. Most of the patients had failed to respond adequately to previous treatment with other therapeutic tools, including acyclovir. Either 50 mg of thymopentin or of placebo was administered 3 times a week, by the subcutaneous route, for 6 weeks. Subsequently, the patients were observed for nearly 6 months on the average. The results achieved with thymopentin for the individual parameters were significantly superior to those obtained with placebo; thus significant improvement was seen in patients on thymopentin in the duration of the longest symptomfree period (prolonged from 2.1 weeks to 20.9 weeks, p = 0.000), in the number of relapses (reduced from 1.6 to 0.4 episodes/month, p = 0.001), and in the total duration of herpes symptoms per month (shortened from 2.0 to 0.3 weeks, p = 0.000). Placebo treatment also resulted in considerable improvement (p < 0.05 or 0.01), but was significantly inferior to the improvement obtained with thymopentin. The longest symptomfree period in the placebo group was prolonged from 2.4 to 11.2 weeks. The number of relapses per month was reduced from 1.4 to 0.8, and the total duration of herpes symptoms per month from 2 to 0.9 weeks. The results of intergroup analyses, in which the observed parameters and the improvement achieved in either group were compared, significantly favored thymopentin treatment. The effect of thymopentin was in all but one parameters superior to that of placebo and highly significant (p < 0.01).read more
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Management of recurrent oral herpes simplex infections
Sook-Bin Woo,Stephen Challacombe +1 more
TL;DR: Evidence suggests that 5% acyclovir (ACV) in the cream base may reduce the duration of lesions if applied early, and further studies are needed to compare treatment efficacy between topical penciclovir, docosanol, and ACV cream for RHL.
Journal ArticleDOI
Interventions for prevention of herpes simplex labialis (cold sores on the lips)
Ching-Chi Chi,Shu-Hui Wang,Finola M Delamere,Fenella Wojnarowska,Mathilde C. Peters,Preetha P. Kanjirath +5 more
TL;DR: The quality of the body of evidence was low to moderate for most outcomes, but was very low for a few outcomes, and the direction of intervention effect was unrelated to the risk of bias.
Journal ArticleDOI
A randomized controlled trial of thymopentin therapy in patients with chronic hepatitis B
Giovanna Fattovich,G. Giustina,Alfredo Alberti,Maria Guido,Patrizia Pontisso,Susanna Favarato,L. Benvegnù,Arturo Ruol +7 more
TL;DR: The results indicate that this regimen of thymopentin therapy is not effective in treating chronic hepatitis B.
Patent
Recombinant human thymopoietin proteins and uses therefor
Crafford A. Harris,Gideon Goldstein,John Siekierka,Mary Anne Talle,Ponniah Shenbagamurthi,Michael D. Culler,Diane R. Setcavage +6 more
TL;DR: In this paper, the nucleotide and amino acid sequences for human thymopoietin α, β, and γ were provided, and methods of recombinantly expressing same, and diagnostic and therapeutic uses thereof.
Journal ArticleDOI
Amino Acid Sequence of Thymopoietin Isolated from Skin
Tapan Audhya,Gideon Goldstein +1 more
TL;DR: Experimental evidence suggests that thymopoietin in the circulation derives from the thymus and not from the skin, suggesting that the thyanofiltration in keratinocytes has a local function, either apocrine and/or immunoregulatory.
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