Patent
Process for making 5-substituted pyrazoles using dithietanes
Matthew J. Graneto,Susan J. Hartmann,Suzanne Metz,John J. Talley,Vazquez Michael L,David L. Brown,Richard M. Weier,Stealey Michael A,Xiangdong Xu +8 more
TLDR
In this article, a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors is described. But the process is not described.Abstract:
This invention relates to a novel process of preparing selected 5-substituted pyrazoles useful as p38 kinase and COX-2 inhibitors.read more
Citations
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Patent
Substituted pyrazoles as p38 kinase inhibitors
Anantanarayan Ashok,John E. St. Louis Baldus,Michael Clare,Paul W. Collins,Joyce Z. Crich,Rajesh Ballwin Devraj,Daniel L. Flynn,Lifeng Geng,Matthew J. Graneto,Cathleen E. Hanau,Gunnar J. Hanson,Susan J. Hartmann,Michael St. Charles Hepperle,He Huang,Kevin D. Jerome,Ish K. Khanna,Francis J. Koszyk,Shuyuan Liao,Suzanne Metz,Win Naing,Richard A. Partis,Thao D. Perry,Shashidhar N. Rao,Shaun R. Selness,Michael S. Chesterfield South,Stealey Michael A,John J. Talley,Vazquez Michael L,John K. Walker,Richard M. Weier,Xiangdong Gurnee Xu,Syaulan Chesterfield Yang,Yi Glenview Yu +32 more
TL;DR: A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
Patent
Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
TL;DR: In this article, a 1,4,5-substituted imidazole was used in treating cytokine mediated diseases by inhibiting the production of IL-1 (interleukin-1), IL-8, and TNF (tumor necrosis factor).
Patent
Medicaments for the treatment or prevention of fibrotic diseases
John Edward Park,Gerald Juergen Roth,Armin Heckel,Nveed Chaudhary,Trixi Brandl,Georg Dahmann,Matthias Grauert +6 more
TL;DR: In this article, the use of indolinones of general formula (I) substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof.
Patent
1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
TL;DR: Novel substituted pyrimido[4,5d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors were presented in this article.
Patent
Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect
TL;DR: In this article, the authors provide a comparison of different formulations of cycloxygenase-2 in terms of low water soluability in a large scale setting, where the drug is presented in the form of solid particles, about 25 to 100 by weight of about 1 µM.
References
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Journal ArticleDOI
Über die Ringverengerung von 6H-1,3,4-Thiadiazinen bei Einwirkung von Basen
Journal ArticleDOI
Synthesis of thiocarbonyl and heterocyclic compounds from 2-methylene-1,3-dithietanes
Nobuyuki Okajima,Yoshiyuki Okada +1 more
TL;DR: In this paper, 2-Methyl-1,3-dithietanes bearing electron withdrawing groups on the methylene carbon atom were synthesized and their reactivities were studied.
Journal ArticleDOI
Polarised ketene dithioacetals. Part 50. Reactions of α-aroyl-α-bromoketene dithioacetals with hydrazine hydrate: formation of rearranged pyrazoles
TL;DR: In this paper, the authors showed that α-aroyl-α-bromoketene dithioacetals with hydrazine hydrate yields unexpected pyrazoles, i.e. 3(5)-aryl-5(3)-4-bis(alkylthio)pyrazoles.
Related Papers (5)
Substituted pyrazoles as p38 kinase inhibitors
Anantanarayan Ashok,John E. St. Louis Baldus,Michael Clare,Paul W. Collins,Joyce Z. Crich,Rajesh Ballwin Devraj,Daniel L. Flynn,Lifeng Geng,Matthew J. Graneto,Cathleen E. Hanau,Gunnar J. Hanson,Susan J. Hartmann,Michael St. Charles Hepperle,He Huang,Kevin D. Jerome,Ish K. Khanna,Francis J. Koszyk,Shuyuan Liao,Suzanne Metz,Win Naing,Richard A. Partis,Thao D. Perry,Shashidhar N. Rao,Shaun R. Selness,Michael S. Chesterfield South,Stealey Michael A,John J. Talley,Vazquez Michael L,John K. Walker,Richard M. Weier,Xiangdong Gurnee Xu,Syaulan Chesterfield Yang,Yi Glenview Yu +32 more