J
John K. Walker
Researcher at Saint Louis University
Publications - 66
Citations - 1518
John K. Walker is an academic researcher from Saint Louis University. The author has contributed to research in topics: Efflux & Agonist. The author has an hindex of 19, co-authored 58 publications receiving 1237 citations. Previous affiliations of John K. Walker include University of Missouri–St. Louis & Indiana University.
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Patent
Substituted pyrazoles as p38 kinase inhibitors
Anantanarayan Ashok,John E. St. Louis Baldus,Michael Clare,Paul W. Collins,Joyce Z. Crich,Rajesh Ballwin Devraj,Daniel L. Flynn,Lifeng Geng,Matthew J. Graneto,Cathleen E. Hanau,Gunnar J. Hanson,Susan J. Hartmann,Michael St. Charles Hepperle,He Huang,Kevin D. Jerome,Ish K. Khanna,Francis J. Koszyk,Shuyuan Liao,Suzanne Metz,Win Naing,Richard A. Partis,Thao D. Perry,Shashidhar N. Rao,Shaun R. Selness,Michael S. Chesterfield South,Stealey Michael A,John J. Talley,Vazquez Michael L,John K. Walker,Richard M. Weier,Xiangdong Gurnee Xu,Syaulan Chesterfield Yang,Yi Glenview Yu +32 more
TL;DR: A class of pyrazole derivatives described for use in treating p38 kinase mediated disorders are defined by Formula IA wherein R1, R2, R3 and R4 are as described in the specification.
Journal ArticleDOI
Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis
Colin A. Flaveny,Kristine Griffett,Bahaa El-Dien M. El-Gendy,Melissa Kazantzis,Monideepa Sengupta,Antonio L. Amelio,Arindam Chatterjee,John K. Walker,Laura A. Solt,Theodore M. Kamenecka,Thomas P. Burris,Thomas P. Burris +11 more
TL;DR: In cancer cells, SR9243 significantly inhibited the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression and suggest that LXR inverse agonists may be an effective cancer treatment approach.
Journal ArticleDOI
A Leishmania Ortholog of Macrophage Migration Inhibitory Factor Modulates Host Macrophage Responses
Daniela Kamir,Swen Zierow,Swen Zierow,Lin Leng,Yoonsang Cho,Yira Diaz,Jason W. Griffith,Courtney McDonald,Melanie Merk,Melanie Merk,Robert A. Mitchell,John O. Trent,Yibang Chen,Yuen-Kwan Amy Kwong,Huabao Xiong,Jon J. Vermeire,Michael Cappello,Diane McMahon-Pratt,John K. Walker,Jürgen Bernhagen,Elias Lolis,Richard Bucala +21 more
TL;DR: An ortholog of the cytokine, macrophage migration inhibitory factor, Lm1740MIF, which is produced by the obligate intracellular parasite, Leishmania major, shows significant structural homology with human MIF and inhibits the activation-induced apoptosis of macrophages.
Journal ArticleDOI
Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump.
Narges Abdali,Jerry M. Parks,Keith M. Haynes,Julie L. Chaney,Adam T. Green,David Wolloscheck,John K. Walker,Valentin V. Rybenkov,Jerome Baudry,Jerome Baudry,Jeremy C. Smith,Jeremy C. Smith,Helen I. Zgurskaya +12 more
TL;DR: The discovered EPIs bind to AcrA, a component of the prototypical AcrAB-TolC pump, change its structure in vivo, inhibit efflux of fluorescent probes, and potentiate the activities of antibiotics in Escherichia coli and other Gram-negative bacteria.
Journal ArticleDOI
Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain.
Zhoumou Chen,Timothy M. Doyle,Livio Luongo,Tally M. Largent-Milnes,Luigino Antonio Giancotti,Grant R. Kolar,Silvia Squillace,Silvia Squillace,Serena Boccella,John K. Walker,Alexander L. Pendleton,Sarah Spiegel,William L. Neumann,Todd W. Vanderah,Daniela Salvemini +14 more
TL;DR: Evidence is provided that sphingosine-1-phosphate generated in the dorsal horn of the spinal cord in response to nerve injury drives neuropathic pain by selectively activating the S1P receptor subtype 1 (S1PR1) in astrocytes, and S1PR 1 is established as a target for therapeutic intervention with S1 PR1 antagonists as a class of nonnarcotic analgesics.