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Journal ArticleDOI

Prognostic value of N-terminal pro-atrial and pro-brain natriuretic peptide in patients with acute coronary syndromes.

TLDR
It is suggested that Nt-proBNP measurements provide complementary prognostic information to conventional risk indicators, including troponin I, in patients with non-ST-segment elevation acute coronary syndromes.
Abstract
In summary, we have shown that circulating Nt-proANP and Nt-proBNP levels are associated with early death, but not with nonfatal recurrent AMI, in patients with non-ST-segment elevation acute coronary syndromes. This nested case-control study suggests that Nt-proBNP measurements provide complementary prognostic information to conventional risk indicators, including troponin I.

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Journal ArticleDOI

B-type natriuretic peptide in cardiovascular disease

TL;DR: Measurement of circulating concentrations of B-type natriuretic peptide and the N-terminal fragment of its prohormones and use of recombinant human BNP (nesiritide) and vasopeptidase inhibitors to treat heart failure are focused on.
References
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Journal ArticleDOI

Cardiac-Specific Troponin I Levels to Predict the Risk of Mortality in Patients with Acute Coronary Syndromes

TL;DR: In patients with acute coronary syndromes, cardiac troponin I levels provide useful prognostic information and permit the early identification of patients with an increased risk of death.
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Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease.

TL;DR: Elevated levels of troponin T and C-reactive protein are strongly related to the long-term risk of death from cardiac causes and these markers are independent risk factors, and their effects are additive with respect to each other and other clinical indicators of risk.
Journal ArticleDOI

Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q-wave myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) 11B trial.

TL;DR: Enoxaparin is superior to UFH for reducing a composite of death and serious cardiac ischemic events during the acute management of UA/NQMI patients without causing a significant increase in the rate of major hemorrhage.
Journal ArticleDOI

The prognostic value of serum troponin T in unstable angina.

TL;DR: Cardiac troponin T in serum appears to be a more sensitive indicator of myocardial-cell injury than serum creatine kinase MB activity, and its detection in the circulation may be a useful prognostic indicator in patients with unstable angina.
Journal ArticleDOI

C-Reactive Protein Is a Potent Predictor of Mortality Independently of and in Combination With Troponin T in Acute Coronary Syndromes: A TIMI 11A Substudy

TL;DR: Elevated CRP at presentation in patients with unstable angina or NQMI is correlated with increased 14-day mortality, even in Patients with a negative rapid cTnT assay, which provides complementary information for stratifying patients with regard to mortality risk.
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