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Journal ArticleDOI

B-type natriuretic peptide in cardiovascular disease

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TLDR
Measurement of circulating concentrations of B-type natriuretic peptide and the N-terminal fragment of its prohormones and use of recombinant human BNP (nesiritide) and vasopeptidase inhibitors to treat heart failure are focused on.
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This article is published in The Lancet.The article was published on 2003-07-26. It has received 1038 citations till now. The article focuses on the topics: Brain natriuretic peptide & Natriuretic peptide.

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2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults

TL;DR: The 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and This information is current as of August 30, 2010 http://content.onlinejacc.org/cgi/content/full/53/15/1343 located on the World Wide Web at: The online version of this article, along with updated information and services, is
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Optimal Noninvasive Assessment of Left Ventricular Filling Pressures A Comparison of Tissue Doppler Echocardiography and B-Type Natriuretic Peptide in Patients With Pulmonary Artery Catheters

TL;DR: In intensive care unit patients, mitral E/Ea has a better correlation than BNP with PCWP, and in patients without cardiac disease, BNP appears more accurate than E-type natriuretic peptide for PCWP >15 mm Hg, whereas E-Ea appears more specific in this patient population.
References
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Journal ArticleDOI

A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats

TL;DR: It is concluded that the atrial extract contained an extremely powerful inhibitor of renal tubular NaCl re absorption, which caused a rapid, more than 30-fold increase of sodium and chloride excretions, while urine volume and potassium excretion doubled.
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A new natriuretic peptide in porcine brain

TL;DR: The brain natriuretic peptide (BNP) as mentioned in this paper was identified in porcine brain of a novel peptide of 26 amino acid residues, eliciting a pharmacological spectrum very similar to that of ANP.
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Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations.

TL;DR: N-BNP-guided treatment of heart failure reduced total cardiovascular events, delayed time to first event compared with intensive clinically guided treatment, and changed left-ventricular function, quality of life, renal function, and adverse events were similar in both groups.
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Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.

TL;DR: Results indicate that BNP is a novel cardiac hormone secreted predominantly from the ventricle, and that the synthesis, secretion and clearance of BNP differ from those of ANP, suggesting discrete physiological and pathophysiological roles of HBNP in a dual natriuretic peptide system.
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