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Progression-Free Survival (PFS) by Blinded Independent Central Review (BICR) and Updated Overall Survival (OS) of Sunitinib versus Placebo for Patients with Progressive, Unresectable, Well Differentiated Pancreatic Neuroendocrine Tumor (NET)
Aaron I. Vinik,Eric Van Cutsem,Patricia Niccoli,Jean-Luc Raoul,Yung-Jue Bang,Ivan Borbath,Catherine Lombard-Bohas,Juan W. Valle,Peter Metrakos,Denis Smith,Jen-Shi Chen,D. Hoersch,Daniel Castellano,Hagen F. Kennecke,Joel Picus,Guy van Hazel,Shem Patyna,Dongrui Ray Lu,Richard C. Chao,Eric Raymond +19 more
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This research highlights the need to understand more fully the role of “cell reprograming” in the development of Parkinson’s disease and its role in cancer.Abstract:
EVMS Strelitz Diabetes Research Center and Neuroendocrine Unit, Norfolk, VA; University Hospital Gasthuisberg, Leuven, Belgium; University Hospital Timone, Paoli-Calmettes Institute and RENATEN Network, Marseille, France; Paoli-Calmettes Institute, Marseille, France; Seoul National University Hospital, Seoul, Republic of Korea; Cliniques Universitaires Saint-Luc, Brussels, Belgium; Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France; The Christie NHS Foundation Trust, Manchester, United Kingdom; McGill University Hospital Centre, Montreal, QC, Canada; Medical oncology, University Hospital, Bordeaux, France; Chang Gung Memorial Hospital and Chang Gung University, Taipei, Republic of China; Zentralklinik Bad Berka GmbH, Bad Berka, Germany; Hospital Universitario 12 de Octubre, Madrid, Spain; British Columbia Cancer Agency, Vancouver, BC, Canada; Washington University School of Medicine, St. Louis, MO; University of Western Australia, Perth, Australia; Pfizer Oncology, La Jolla, CA; Beaujon University Hospital, Clichy, Franceread more
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Journal ArticleDOI
A systematic review of non-surgical treatments for pancreatic neuroendocrine tumours
TL;DR: Data from recently conducted studies assessing targeted therapies indicate that it is possible to conduct adequately powered RCTs reporting standardised oncological endpoints in this rare cancer and similarly robust studies should be conducted to define the optimal treatment algorithm.
Journal ArticleDOI
Everolimus, lutetium-177 DOTATATE and sunitinib for advanced, unresectable or metastatic neuroendocrine tumours with disease progression: a systematic review and cost-effectiveness analysis.
Ruben Mujica-Mota,Jo Varley-Campbell,Irina A Tikhonova,Chris Cooper,Ed Griffin,Marcela Haasova,Jaime Peters,Stefano Lucherini,Juan Talens-Bou,Linda Long,David Sherriff,Mark Napier,John Ramage,Martin Hoyle +13 more
TL;DR: The pNETs trials consistently found that the interventions improved PFS and overall survival (OS) compared with BSC, and this trial informs the estimate of the cost-effectiveness of 177Lu-DOTATATE.
Journal ArticleDOI
Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta‐analysis
Martin A. Walter,Cédric Nesti,Marko Spanjol,Attila Kollár,Lukas Bütikofer,Viktoria Gloy,Rebecca A. Dumont,Christian Seiler,Emanuel Christ,Piotr Radojewski,Matthias Briel,Reto Kaderli +11 more
TL;DR: In this paper, the authors evaluated the safety and efficacy of therapies for neuroendocrine tumours, to guide clinical decision-making, and to provide estimates of relative efficiency of the different treatment options (including placebo) and rank the treatments according to their efficiency based on a network meta-analysis.
Journal ArticleDOI
Pharmacokinetics and pharmacodynamics of sunitinib for the treatment of advanced pancreatic neuroendocrine tumors
TL;DR: The role of sunitinib, a multitargeted tyrosine kinase inhibitor with potent antiangiogenic and antitumor effects, in the clinical management of PNET is reviewed, with hopes to further improve overall survival in this once difficult-to-treat set of patients in the coming years.