Journal ArticleDOI
Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease
Klaus Fassbender,Siegbert Rossol,Thomas Kammer,Michael Daffertshofer,Steffen Wirth,Martina Dollman,Michael G. Hennerici +6 more
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TLDR
The increase of levels of IL-6 despite a considerable dilution in peripheral blood shown in this preliminary study suggests an early inflammatory response in ischemic brain lesion.About:
This article is published in Journal of the Neurological Sciences.The article was published on 1994-04-01. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine & Lesion.read more
Citations
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Interleukin-1 and neuronal injury
TL;DR: There is now extensive evidence to support the direct involvement of interleukin-1 in the neuronal injury that occurs in both acute and chronic neurodegenerative disorders, and a rationale for targeting the interleuko-1 system as a therapeutic strategy is provided.
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Inflammation and glial responses in ischemic brain lesions
TL;DR: It is unclear whether detrimental effects of inflammation outweigh neuroprotective mechanisms or vice versa, and in global ischemia inflammatory responses are limited, but micro- and astroglia are also strongly activated.
Journal ArticleDOI
Proinflammatory Cytokines and Early Neurological Worsening in Ischemic Stroke
TL;DR: The association between IL-6 and early neurological worsening prevails without regard to the initial size, topography, or mechanism of the ischemic infarction.
Journal ArticleDOI
Inflammation in stroke and focal cerebral ischemia
TL;DR: Inflammatory interactions that occur at the blood-endothelium interface, involving cytokines, adhesion molecules, chemokines and leukocytes, are critical to the pathogenesis of tissue damage in cerebral infarction.
Journal ArticleDOI
The immunology of acute stroke.
Ángel Chamorro,Andreas Meisel,Anna M. Planas,Xabier Urra,Diederik van de Beek,Roland Veltkamp +5 more
TL;DR: The multifaceted role of the immune system in the pathophysiology of acute stroke is discussed, with increased incidence of infections observed after acute stroke, and might result from activation of long-distance feedback loops between the CNS and peripheral immune organs.
References
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Journal ArticleDOI
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
TL;DR: It is demonstrated that monocyte-derived hepatocyte-stimulating factor and IFN-beta 2 share immunological and functional identity and that IFN -beta 2, also known as B-cell stimulatory factor and hybridoma plasmacytoma growth factor, has the hepatocyte as a major physiologic target and thereby is essential in controlling the hepatic acute phase response.
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Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF).
TL;DR: With IL 6 transgenic mice, deregulation of the IL 6 expression was suggested to be involved in the generation of plasmacytoma/myeloma and mesangium proliferative glomerulonephritis and the findings suggest the presence of a positive regulatory loop in acute‐phase reaction.
Journal Article
Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.
TL;DR: The results suggest that progressive leukocyte capillary plugging during myocardial ischemia contributes to preventing full restoration of capillary flow upon reperfusion.
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Interleukin-1 stimulation of astroglial proliferation after brain injury.
Dana Giulian,Lawrence B. Lachman +1 more
TL;DR: Findings suggest that interleukin-1, released by inflammatory cells, may promote the formation of scars by astroglia in the damaged mammalian brain.