Prostaglandin-Like Substances Appearing in Canine Renal Venous Blood During Renal Ischemia
J. C. McGiff,Keith Crowshaw,Norberto A. Terragno,Andrew J. Lonigro,James C. Strand,Mary Anne Williamson,James B. Lee,Kevin K. F. Ng +7 more
TLDR
Renal venous blood and renal medullary tissue were extracted for acidic lipids and assayed for prostate prostaglandins (PCs) like substances as mentioned in this paper, which indicated that they are predominantly a mixture of PGE2 and PGF2α.Abstract:
Renal prostaglandins (PCs) might mediate an antihypertensive function of the kidney. The blood-superfused organ technique possesses the sensitivity (threshold < 0.4 ng/ml blood) and specificity required for identification of PGs in blood. Induction of unilateral renal ischemia in 14 chloraloseanesthetized dogs reduced renal blood flows from a mean value of 257 to 109 ml/min on the ischemic side and from 250 to 209 ml/min on the contralateral side. Concomitantly, PG-like substances were detected by assay organs in the venous blood of ischemic (13 experiments) and contralateral (11 experiments) kidneys. In one experiment, in a spontaneously hypertensive dog, PGs were not detected during renal ischemia.
Renal venous blood and renal medullary tissue were extracted for acidic lipids and assayed for PG-like substances. Extracts of venous blood collected during renal ischemia and extracts of renal medulla yielded substances with biological activity indistinguishable from PG-like substances or PG standards. Chromatographic characterization of PG-like substances suggests that they are predominantly a mixture of PGE2 and PGF2α.read more
Citations
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Angiotensin Receptors and Their Antagonists
TL;DR: The intrarenal renin–angiotensin system affects glomerular filtration, as discussed below, but the importance of ang Elliotensin synthesis in other tissues is not known.
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Release of a Prostaglandin E-Like Substance from Canine Kidney by Bradykinin
TL;DR: Results suggest that a prostaglandin E-like substance participates in the renal vasodilator and the diuretic responses to bradykinin, which is correlated with changes in renal venous concentrations of substances having the properties of prostag landins of the E and F series in anesthetized dogs.
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