Journal ArticleDOI
Prostaglandins: Their Disappearance from and Release into the Circulation
S. H. Ferreira,John R. Vane +1 more
TLDR
The liver and lungs provide an efficient protective mechanism to remove almost all the prostaglandin before it reaches the arterial circulation.Abstract:
Prostaglandins are released into the splenic venous blood when the spleen contracts Whatever the significance of this release, the liver and lungs provide an efficient protective mechanism to remove almost all the prostaglandin before it reaches the arterial circulationread more
Citations
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
Journal ArticleDOI
Biologically active products of stimulated liver macrophages (Kupffer cells)
TL;DR: Topological factors seem to influence their final differentiation and to endow each type with particular metabolic and structural features in the body’s defensive machinery.
Journal ArticleDOI
Indomethacin and aspirin abolish prostaglandin release from the spleen.
TL;DR: The action of these two anti-inflammatory agents provides further support for the suggestion that some of their therapeutic effects depend on the inhibition of the production of prostaglandin.
Journal ArticleDOI
The eicosanoids and their biochemical mechanisms of action.
TL;DR: Low dosages of aspirin and ingestion of certain fish oils have recently been touted as having some value in preventing cardiovascular disease.
Journal ArticleDOI
Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs
Priscilla J. Piper,John R. Vane +1 more
TL;DR: Among the active substances released during anaphylaxis in guinea-pig lung is a hitherto unidentified substance which has a contracting effect on rabbit aorta.
References
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Journal ArticleDOI
The use of isolated organs for detecting active substances in the circulating blood. 1964.
TL;DR: In this paper, a method is described for the assay of circulating hormones after their injection or release into the circulation, which is applicable to cats, dogs and rabbits, and consists of bathing or superfusing isolated smooth muscle preparations in a stream of heparinized arterial blood.
Journal ArticleDOI
Prostaglandins and related factors. 28. metabolism of prostaglandin e1 in guinea pig lung: the structures of two metabolites.
Journal ArticleDOI
Observations on the Effects of Infusion of Prostnglnndin E in Man
TL;DR: The experiment showed that even small amounts of the PGE elicited marked and long lasting effects some persisting for as long as 15 minutes after the end of infusions.
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Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs
Priscilla J. Piper,John R. Vane +1 more