Journal ArticleDOI
Proton spectroscopy without water suppression: the oversampled J-resolved experiment.
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TLDR
A method is introduced for obtaining proton spectra in vivo with all the advantages of a full water signal, based on F1 oversampled J‐resolved spectroscopy, that makes it possible to separate metabolite signals from unwanted baseline artifacts.Abstract:
A method is introduced for obtaining proton spectra in vivo with all the advantages of a full water signal. The method, based on F1 oversampled J-resolved spectroscopy, makes it possible to separate metabolite signals from unwanted baseline artifacts. The dominant water resonance is used as a 2D reference signal for the phase-sensitive reconstruction of the 2D J-resolved metabolite spectra. The powerful specificity of this method is demonstrated with model compound spectra, phantoms, and in vivo examples.read more
Citations
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Journal ArticleDOI
Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study.
TL;DR: This study suggests a possible role of altered glutamatergic neurotransmission within the anterior cingulate in the pathogenesis of mood disorders.
Journal ArticleDOI
Toward an in Vivo Neurochemical Profile: Quantification of 18 Metabolites in Short-Echo-Time 1H NMR Spectra of the Rat Brain
TL;DR: Frequency domain analysis with LCModel showed that the in vivo spectra can be explained by 18 metabolite model solution spectra and a highly structured background, which was attributed to resonances with fivefold shorter in vivo T(1) than metabolites.
Journal ArticleDOI
Issues of spectral quality in clinical 1H-magnetic resonance spectroscopy and a gallery of artifacts
TL;DR: This article aims to increase interest in issues of spectral quality and quality assessment, to start a larger debate on generally accepted criteria that spectra must fulfil to be clinically and scientifically acceptable, and to provide a sample gallery of artifacts, which can be used to raise awareness for potential pitfalls in MRS.
Journal ArticleDOI
Magnetic resonance spectroscopy of the human brain
Brian D. Ross,Stefan Bluml +1 more
TL;DR: Practical aspects of in vivo MRS are described with particular emphasis on the brain, where novel metabolites have been described and add a new dimension to anatomic and histopathologic descriptions.
Journal ArticleDOI
Measurement of brain glutamate using TE-averaged PRESS at 3T.
Ralph E. Hurd,Napapon Sailasuta,Radhika Srinivasan,Daniel B. Vigneron,Daniel Pelletier,Sarah J. Nelson +5 more
TL;DR: A method is introduced that provides improved in vivo spectroscopic measurements of glutamate (Glu), glutamine (Gln), choline (Cho), creatine (Cre), N‐acetyl compounds (NAtot, NAA + NAAG), and the inositols (mI and sI), and it was found that at 3T, TE averaging, the f1 = 0 slice of a 2D J‐resolved spectrum, yielded unobstructed signals.
References
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Journal ArticleDOI
Homonuclear broad band decoupling and two-dimensional J-resolved NMR spectroscopy
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Absolute Quantitation of Water and Metabolites in the Human Brain. II. Metabolite Concentrations
TL;DR: In this paper, a method for determining absolute metabolite concentrations with in vivo 1H magnetic resonance spectroscopy is presented, involving the measurement of an external standard as well as of the localized water signal.
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Absolute Quantitation of Water and Metabolites in the Human Brain. I. Compartments and Water
TL;DR: The compartmentation model can be used to correct for the CSF content of the selected volume and to properly define and interconvert all major concentration units and has major applications in localized quantitative spectroscopy.
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Automated single-voxel proton MRS: Technical development and multisite verification
TL;DR: An integrated method to automatically acquire and process single‐voxel in vivo proton spectra on a 1.5 T clinical scanner indicates that automated setting of acquisition and processing parameters is of critical importance in the clinical application of in vivo spectroscopy.
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On the identification of cerebral metabolites in localized 1H NMR spectra of human brain In vivo
Thomas Michaelis,Klaus-Dietmar Merboldt,Wolfgang Hänicke,Michael L. Gyngell,Harald Bruhn,Jens Frahm +5 more
TL;DR: The assignment of 1H NMR resonances of cerebral metabolites under the experimental conditions used for human investigations shows enhanced levels of cerebral glutamine detected in patients with liver cirrhosis, and for the first time elevated levels of brain glucose are observed in Patients with diabetes mellitus.