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Showing papers in "Magnetic Resonance Imaging in 1995"


Journal Article•DOI•
TL;DR: The application of MRI segmentation for tumor volume measurements during the course of therapy is presented here as an example, illustrating problems associated with inter- and intra-observer variations inherent to supervised methods.

752 citations


Journal Article•DOI•
TL;DR: The bulk physiochemical properties of the active ingredients in three AMI colloidal, superparamagnetic iron oxide (SPIO), MR contrast agents are described and ferrous content and X-Ray diffraction of the colloids are consistent with nonstoichiometric magnetite phases in all three active ingredients.

636 citations


Journal Article•DOI•
TL;DR: This study demonstrates that diffusion-weighted imaging detects both the core and the penumbra of the evolving infarction but is not able to differentiate between the two parts.

244 citations


Journal Article•DOI•
TL;DR: The surface properties of the active ingredients in AMI colloidal, superparamagnetic iron oxide magnetic resonance (MR) contrast agents are described and the nature of the interactions of the dextran coating with the iron oxide surfaces of ferumoxides and Ferumoxtran is discussed.

225 citations


Journal Article•DOI•
TL;DR: MRI can be used to evaluate the extent of synovitis, observed as synovial thickening, in patients with early OA of the knee, and thus a correspondence with the synovia thickening detected by MRI is suggested.

202 citations


Journal Article•DOI•
TL;DR: It is suggested that the reproducibility of RV measurements is adequate to detect RV hypertrophy and a low ejection fraction in the individual patient and more effort is needed to improve the reproduCibility of MR imaging measurements.

193 citations


Journal Article•DOI•
TL;DR: High resolution 1H NMR spectroscopy was used to analyze temporal lobe biopsies obtained from patients with epilepsy, finding thataired in vivo and ex vivo measurements are critical for a firm understanding of the changes seen in the 1H-spectra.

158 citations


Journal Article•DOI•
TL;DR: The process of producing magnetic resonance (MR) volume measurements can be divided into considerations of acquisition and postprocessing of the MR data, and the statistical description of "normal" should be determined or calibrated at each institution wishing to use these techniques.

156 citations


Journal Article•DOI•
TL;DR: Based on the results of neuropathologic correlation, the application of FCM MR image segmentation to several MR images of a glioblastoma multiforme represents a viable technique for displaying diagnostically relevant tissue contrast information used in 3D volume reconstruction.

153 citations


Patent•DOI•
TL;DR: In this article, compositions comprising imaging agent(s) contained within polymeric shells are provided, for example, as contrast agents for magnetic resonance imaging (MRI), ultrasonography, and X-ray computer tomography.

133 citations


Journal Article•DOI•
TL;DR: A brain phantom was developed to mimic the gray matter of human brain with the metabolites at physiological concentrations (0.5-12 mM) and in vivo 2D J-PRESS spectra of healthy human brain were in conformity with those recorded from the brain phantom.

Journal Article•DOI•
TL;DR: The results for SFCM suggest that it should be useful for relative measurements of tumor volume during therapy, but further studies are required, and demonstrates the need for minimally supervised or unsupervised methods for tumor volume measurements.

Journal Article•DOI•
TL;DR: Combining the results of refined imaging techniques holds great promise in epilepsy localization and diagnosis because they measure different aspects of the epileptic process--structure, metabolism, and perfusion.

Journal Article•DOI•
TL;DR: MR imaging, when combined with in vivo MRS, may help to better characterize intracranial cystic mass lesions and be differentiated from arachnoid cysts by the presence of alanine.

Journal Article•DOI•
TL;DR: Partial biodistribution studies with the 111In-labeled liposomes revealed that PEG-modified vesicles accumulated in the axillary lymph node at half the amount comparing with nonmodified and dextran-modified liposome, which might be explained by noticeably increased relaxivity of PEG -modified Gd-liposomes.

Journal Article•DOI•
TL;DR: Variations demonstrate significant changes in attenuation curves between rest and postexercise in skeletal muscle and may support an interpretation of the long and the short components in terms of a microvascular and an extra-microvascular compartments.

Journal Article•DOI•
TL;DR: The chelates containing long alkyl side chains, such as Gd(DTPA-HPA2), showed increased relaxivity values in the presence of human serum albumin (HSA), indicative of noncovalent interaction with the protein, which could be useful as nonionic hepatobiliary contrast agents.

Patent•DOI•
TL;DR: These novel emulsions have various medical applications and are especially useful medically as contrast media for various biological imaging modalities such as nuclear magnetic resonance, 19 F-magnetic resonance imaging, ultrasound, x-ray, and computed tomography.

Journal Article•DOI•
TL;DR: T2-QMRI measurement of T2 relaxation time is more accurate than SI ratios in evaluating liver iron overload, particularly useful for hemosiderotic patients with coexisting hepatitis since, in this case, serum ferritin is not considered a reliable index of hemosIDERosis.

Journal Article•DOI•
TL;DR: The study demonstrates the feasibility of accurate and precise nontriggered velocity measurements for weakly pulsatile flow and indicates a route towards improving the reliability for highly pulsatileflow.

Journal Article•DOI•
TL;DR: A technique which allows to perform MCA occlusion inside the magnet under simultaneous recording of EEG and direct current (DC) potentials for monitoring the ischemic insult in rats is developed.

Journal Article•DOI•
Gary W. Van Hoesen1•
TL;DR: With magnetic resonance imaging (MRI), previous neuroanatomical detail, which earlier may have seemed like descriptive minutia, has now come alive and assumed substantial relevance in neurological and psychiatric diagnosis.

Journal Article•DOI•
TL;DR: Early application of MRI can more accurately classify the disease process and focus the differential diagnosis, thus avoiding the hazards of medical therapy associated with other etiologies such as deep venous thrombosis, cellulitis, or osteomyelitis.

Journal Article•DOI•
TL;DR: It is concluded that both T2 and ADC with exercise are probably different, T2 mostly reflecting changes in water content and ADC reflecting temperature variations.

Journal Article•DOI•
TL;DR: RMU is able to differentiate a physiological from a pathologic ureterohydronephrosis during pregnancy and could be considered as a procedure of choice for special cases when US failed to establish this differential diagnosis.

Journal Article•DOI•
TL;DR: The biodistribution of targeted and blood pool 153Gd/111In labeled proteins suggested that gadolinium dissociates from protein- DTPA and protein-MX-DTPA and their metabolites leading to an accumulation of gadolinia in bone.

Journal Article•DOI•
TL;DR: The partial saturation inversion recovery sequence provided excellent contrast-to-noise for white to grey matter and consistently visualized the thalamic nuclear groups, hippocampal fine structure, as well as small draining vessels of the white matter.

Journal Article•DOI•
TL;DR: The longer-lived component, not identified previously in vivo, provides a significant contrast-to-noise ratio (CNR) between nerve and muscle in the latter-echo images and can be further improved by the averaging of selected images from the multi-echo set.

Journal Article•DOI•
TL;DR: It is concluded that regional cerebral hemodynamics are observable by fMRI in man and this may have clinical applications.

Journal Article•DOI•
Gregory D. Cascino1•
TL;DR: MRI-identified hippocampal atrophy appears to serve an in vivo surrogate for the presence of MTS, and the relationship between the duration of the seizure disorder and volumetry is conflicting.