Journal ArticleDOI
Pulmonary toxicity after radiation and bleomycin: a review
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TLDR
Review of the literature regarding clinical studies using BLM and irradiation indicates that the incidence of pulmonary toxicity increases when bleomycin is administered in conjunction with radiotherapy to the thorax.Abstract:
The effects of bleomycin (BLM) and radiation on the lung are histologically similar Animal studies have indicated additive or synergistic effects from these 2 agents Review of the literature regarding clinical studies using BLM and irradiation indicates that the incidence of pulmonary toxicity increases when bleomycin is administered in conjunction with radiotherapy to the thorax Of 115 patients treated simultaneously with BLM and radiation to the thorax, 22 (19%) suffered pulmonary toxicity that was fatal in 11 (10%)read more
Citations
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Injury to the lung from cancer therapy: Clinical syndromes, measurable endpoints, and potential scoring systems
TL;DR: The development of staging systems for acute and late toxicity is discussed and a new staging system for Late Effects in Normal Tissues (LENT) is proposed.
Journal ArticleDOI
Pulmonary Radiation Injury
Journal ArticleDOI
Mechanisms of bleomycin-induced lung damage
TL;DR: Bleomycins are a family of compounds produced by Streptomyces verticillis which have potent tumour killing properties which have given them an important place in cancer chemotherapy.
Journal ArticleDOI
Radiation Pulmonary Toxicity: From Mechanisms to Management
TL;DR: The current knowledge of the molecular and cellular events that occur after radiation therapy, the clinical manifestations of radiation-induced lung injury, current strategies to minimize lung injury and recent experimental methods to reduce lung injury are discussed and their potential for translation into the clinic are discussed.
Journal ArticleDOI
Bleomycin-induced pulmonary toxicity.
TL;DR: The clinical setting and presentation, radiographic manifestations, pathologic findings, and the prognosis of bleomycin-induced interstitial fibrosis are described and the role of pulmonary function tests in monitoring patients for toxicity is discussed.
References
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Journal ArticleDOI
A clinical review of bleomycin—a new antineoplastic agent
TL;DR: In conclusion, bleomycin appeared to be useful in the treatment of patients with specific tumors refractory to standard treatment and/or whose bone marrow status precluded the use of conventional chemotherapy.
Journal ArticleDOI
Bleomycin, an Antitumor Antibiotic: Clinical Experience in 274 Patients
Alan Yagoda,Bijay Mukherji,Charles W. Young,Erlinda Etcubanas,Charles Lamonte,Julius R. Smith,Charlotte Tan,Irwin H. Krakoff +7 more
Journal ArticleDOI
The mechanism of the bleomycin-induced cleavage of DNA.
J. William Lown,Soo-Khoon Sim +1 more
TL;DR: It is shown that 2-Mercaptoethanol, dithiothreitol, ascorbic acid and xanthine/xanthine oxidase, hitherto commonly used with bleomycin studies, separately cleave DNA by a similar mechanism.
Journal ArticleDOI
Radiation pneumonitis: a new approach to the derivation of time-dose factors.
TL;DR: A series of 51 patients treated with 92 separate lung fields for metastatic pulmonary disease between 1958 and 1971 is reviewed and a newly derived formula for estimated single doses (ED) is developed.