Patent
Pyrazolo [3, 4-d] pyrimidine derivatives useful to treat respiratory disorders
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TLDR
In this article, a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R1-R3 and Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicated, is described.Abstract:
The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R1-R3 and Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicatedread more
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Patent
Heterocyclic compounds and uses thereof
Alfredo C. Castro,Catherine A. Evans,Somarajannair Janardanannair,Andre Lescarbeau,Tao Liu,Daniel A. Snyder,Martin R. Tremblay,Pingda Ren,Yi Liu,Liansheng Li,Katrina Chan +10 more
TL;DR: In this article, compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activation, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activations are described.
Patent
Certain chemical entities, compositions and methods
TL;DR: In this paper, chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 Kinase activity are described.
Patent
Inhibitors of pi3 kinase
Yunxin Y. Bo,Shon Booker,Marian C. Bryan,Holly L. Deak,Longbin Liu,Kristin L. Andrews,Nobuko Nishimura,Mark H. Norman,Kathleen Panter,Laurie B. Schenkel,Aaron C. Siegmund,Nuria A. Tamayo,Kevin Yang +12 more
TL;DR: In this article, the present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined as defined herein.
Patent
Heterocyclic kinase inhibitors
TL;DR: In this paper, the authors provide heterocyclic compounds for use as P13 kinase inhibitors and in other applications, as well as pharmaceutical compositions and methods of treatments of diseases and conditions associated with P 13 kinase activity.
Patent
Kinase inhibitors and methods of use
TL;DR: In this article, chemical entities or compounds and pharmaceutical compositions thereof are provided that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases.
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Journal ArticleDOI
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
Zachary A. Knight,Beatriz González,Morri E. Feldman,Eli R. Zunder,David D. Goldenberg,Olusegun Williams,Robbie Loewith,David Stokoe,András Balla,Balazs Toth,Tamas Balla,William A. Weiss,Roger L. Williams,Kevan M. Shokat +13 more
TL;DR: It is found that p110alpha is the primary insulin-responsive PI3-K in cultured cells, whereas p110beta is dispensable but sets a phenotypic threshold for p110 alpha activity, which illustrates systematic target validation using a matrix of inhibitors that span a protein family.
Patent
Pyrazolopyrimidines as therapeutic agents
Gavin C. Hirst,Paul Rafferty,Kurt Ritter,David J. Calderwood,Neil Wishart,Arnold Lee D,Michael M. Friedman +6 more
TL;DR: In this paper, the present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described as described in this paper.
Patent
Inhibitors of human phosphatidylinositol 3-kinase delta
Chanchal Sadhu,Kenneth O. Dick,Jennifer Treiberg,C. Gregory Sowell,Edward A. Kesicki,Amy Oliver +5 more
TL;DR: In this paper, the authors provide methods of using PI3Kδ inhibitory compounds to inhibit PI-3K-δ-mediated processes in vitro and in vivo.
Patent
Aminobenzoxazoles as therapeutic agents
Neil Wishart,Michael M. Friedman,Arnold Lee D,Bryant Yang,Shannon R. Fix-Stenzel,Anna M. Ericsson,Michael R. Michaelides,Xiao-Dong Qian,James H. Holmes,Douglas H. Steinman,Zhengping Tian,Steven J. Wittenberger +11 more
TL;DR: A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors is defined in this paper, where the substitutions are defined as:
Patent
Anti-inflammatory pyrazolopyrimidines
TL;DR: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition as discussed by the authors.