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QSAR Analysis of Isosteviol Derivatives as α-Glucosidase Inhibitors with Element Count and Other Descriptors
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This article is published in Letters in Drug Design & Discovery.The article was published on 2011-01-01. It has received 17 citations till now.read more
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Studies on α-Glucosidase Inhibitors Development: Magic Molecules for the Treatment of Carbohydrate Mediated Diseases
TL;DR: It is concluded that many α-glucosidases inhibitors obtained from natural products are used for the treatment of various carbohydrate mediated diseases and the structural analysis of these synthetic and natural derivatives guide for the development of novel semisynthetic/synthetic α- glucosIDase inhibitors with free of toxicities.
Journal ArticleDOI
Bioactivity Profile of the Diterpene Isosteviol and its Derivatives.
TL;DR: The present review is an effort to integrate recently developed novel drugs syntheses from isosteviol and potentially active pharmacological importance of the issteviol derivatives covering the recent advances.
Journal ArticleDOI
Synthesis, cytotoxic activity evaluation and HQSAR study of novel isosteviol derivatives as potential anticancer agents.
TL;DR: A series of novel isosteviol derivatives bearing amino alcohol and thiourea fragments have been stereo-selectively synthesized and screened for their in-vitro cytotoxic activities against three human cancer cell lines and demonstrated that these compounds exhibited prominent cytot toxicities.
Journal ArticleDOI
Structural analysis of α-glucosidase inhibitors by validated QSAR models using topological and hydrophobicity based descriptors
TL;DR: The presence of balanced hydrophobic and hydrophilic properties on the vdW surface area is responsible for hydrogen bonding and other electrostatic interaction (aromatic) of inhibitors with the enzyme for favorable α-glucosidase inhibitory activity.
Journal ArticleDOI
Analysis of van der Waals surface area properties for human ether-a-go-go-related gene blocking activity: computational study on structurally diverse compounds
TL;DR: These studies provided additional information on the importance of vdW surface area properties for the hERG blocking activity and can be used with other molecular modelling studies for the design of novel molecules that are free of cardiotoxicity.