Journal ArticleDOI
Quantification of left ventricular internal flow from cardiac magnetic resonance images in patients with dyssynchronous heart failure.
Brandon K. Fornwalt,Brandon K. Fornwalt,Patrick C Gonzales,Jana G. Delfino,Robert L. Eisner,Angel R. Leon,John N. Oshinski,John N. Oshinski +7 more
TLDR
To develop a method for quantifying left ventricular internal flow as a measure of dyssynchrony using standard cine cardiac magnetic resonance (CMR) images.Abstract:
Purpose
To develop a method for quantifying left ventricular (LV) internal flow as a measure of dyssynchrony using standard cine cardiac magnetic resonance (CMR) images.
Materials and Methods
CMR images were obtained from 10 healthy controls and 10 patients with dyssynchronous heart failure (class III/IV, LV ejection fraction 150 msec). The LV volume was reconstructed and divided into 16 regions. Internal flow was defined as the sum of the regional volume changes minus the global volume change during each time step in the cardiac cycle. Internal flow fraction (IFF) was defined as the total internal flow as a percentage of stroke volume during systole (IFFsystole), diastole (IFFdiastole), or the whole cycle (IFFwhole).
Results
IFFwhole was significantly increased in the patients (9.9 ± 5.0% vs. 1.5 ± 0.5% in the controls, P < 0.001). An IFFwhole threshold of 4% discriminated between patients and controls with 90% sensitivity and 100% specificity. IFFdiastole (2.3 ± 0.8%) was greater than IFFsystole (0.8 ± 0.5%) in the normal controls (P < 0.001) while the patients had similar IFFdiastole (7.8 ± 4.2%) and IFFsystole (12.0 ± 7.8%).
Conclusion
Left ventricular internal flow fraction can be quantified from standard CMR images. In this preliminary study, Left ventricular internal flow fraction discriminated patients with dyssynchronous heart failure from normal controls with 95% accuracy. J. Magn. Reson. Imaging 2008;28:375–381. © 2008 Wiley-Liss, Inc.read more
Citations
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Journal ArticleDOI
Cardiac resynchronization therapy guided by cardiovascular magnetic resonance
TL;DR: The role of CMR is focused on in the assessment of patients undergoing CRT, with emphasis on risk stratification and LV lead deployment.
Journal ArticleDOI
It's Time for a Paradigm Shift in the Quantitative Evaluation of Left Ventricular Dyssynchrony
TL;DR: Techniques to quantify LV mechanical dyssynchrony need to be refined, not forgotten, and will still play a role in improving CRT selection criteria in the future, but requires a paradigm shift.
Journal ArticleDOI
Current and future role of cardiovascular magnetic resonance in cardiac resynchronization therapy.
Francisco Leyva,Paul W X Foley +1 more
TL;DR: The current role of CMR in risk stratification and in guiding LV lead deployment is explored and the potential of C MR in identifying the arrhythmogenic substrate is also discussed.
Journal ArticleDOI
Method to create regional mechanical dyssynchrony maps from short-axis cine steady-state free-precession images.
Jonathan D. Suever,Brandon K. Fornwalt,Lee R. Neuman,Jana G. Delfino,Michael Lloyd,John N. Oshinski,John N. Oshinski +6 more
TL;DR: In this paper, the authors developed a robust method to assess regional mechanical dyssynchrony from cine short-axis MR images using radial displacement curves (RDCs) generated throughout the endocardial boundary.
Journal ArticleDOI
Role of MRI in patient selection for CRT.
TL;DR: The goal of this manuscript is to review the MRI methods that can be used in the selection of patients for CRT and to map the location of cardiac venous anatomy.
References
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Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart A Statement for Healthcare Professionals From the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
Manuel D. Cerqueira,Neil J. Weissman,Vasken Dilsizian,Alice K. Jacobs,Sanjiv Kaul,Warren K. Laskey,Dudley J. Pennell,John A. Rumberger,Thomas J. Ryan,Mario S. Verani +9 more
TL;DR: Attempts to standardize options for all cardiac imaging modalities should be based on the sound principles that have evolved from cardiac anatomy and clinical needs, and selection of standardized methods must bebased on the following criteria.
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The effect of cardiac resynchronization on morbidity and mortality in heart failure
John G.F. Cleland,Jean-Claude Daubert,Erland Erdmann,Nick Freemantle,Daniel Gras,Lukas Kappenberger,Luigi Tavazzi +6 more
TL;DR: Cardiac resynchronization has been shown to reduce symptoms and improve left ventricular function in patients with heart failure due to systolic dysfunction and cardiac dyssynchrony.
Journal ArticleDOI
Standardized Myocardial Segmentation and Nomenclature for Tomographic Imaging of the Heart
Manuel D. Cerqueira,Neil J. Weissman,Vasken Dilsizian,Alice K. Jacobs,Sanjiv Kaul,Warren K. Laskey,Dudley J. Pennell,John A. Rumberger,Thomas J. Ryan,Mario S. Verani +9 more
TL;DR: A remarkable committee was convened: The American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging came to an agreement upon all aspects of nomenclature and anatomic descriptions of the heart.
Journal ArticleDOI
Results of the Predictors of Response to CRT (PROSPECT) Trial
Eugene S. Chung,Angel R. Leon,Luigi Tavazzi,Jing Ping Sun,Petros Nihoyannopoulos,John D. Merlino,William T. Abraham,William T. Abraham,Stefano Ghio,Christophe Leclercq,Jeroen J. Bax,Cheuk-Man Yu,John Gorcsan,Martin St. John Sutton,Johan De Sutter,Jaime Murillo +15 more
TL;DR: No single echocardiographic measure of dyssynchrony may be recommended to improve patient selection for CRT beyond current guidelines, given the modest sensitivity and specificity of these parameters in this multicenter setting.
Journal ArticleDOI
Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association
Manuel D. Cerqueira,Neil J. Weissman,Vasken Dilsizian,Alice K. Jacobs,Sanjiv Kaul,Warren K. Laskey,Dudley J. Pennell,John A. Rumberger,Thomas J. Ryan,Mario S. Verani +9 more
TL;DR: In this article, the authors proposed a standardization of the angles for cardiac planes, number of segments, slice display and thickness, nomenclature for segments and assignment of segments to coronary arterial territories.