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quantitated with 3a-hydroxysteroid dehydrogenase
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The article was published on 1987-01-01 and is currently open access. It has received 0 citations till now. The article focuses on the topics: Hydroxysteroid dehydrogenase.read more
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Journal ArticleDOI
The physicochemical basis of cholesterol gallstone formation in man
William H. Admirand,Donald Small +1 more
TL;DR: The physical state of bile is suggested that the presence or absence of insoluble cholesterol is determined by the relative concentrations of biles salt, lecithin, and cholesterol, and the other biliary constituents do not appear to significantly effect the solubility of cholesterol in bile.
Journal ArticleDOI
Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile.
S D Turley,J M Dietschy +1 more
TL;DR: It was established that the bile acid concentration in bile samples with a high molar percentage of cholesterol would be overestimated if 3 beta-hydroxysteroid dehydrogenase were present with the 3 alpha-enzyme.
Journal ArticleDOI
Glucuronidation of 6 alpha-hydroxy bile acids by human liver microsomes.
TL;DR: Results indicate that 6 alpha-hydroxylation followed by 6-O-glucuronidation constitutes an alternative route of excretion of toxic hydrophobic bile acids.
Journal ArticleDOI
Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in man.
TL;DR: Analysis of urinary bile acids showed that a large proportion of the administered hyodeoxycholic acid was excreted by the kidney as a glucuronide, which does not support the existence of intestinal bacterial 6 alpha-dehydroxylases.
Journal ArticleDOI
Bile acids secretion and synthesis by isolated rat hepatocytes
M. S. Anwer,R. Kroker,D. Hegner +2 more
TL;DR: It is suggested that isolated hepatocytes synthesize and secrete bile acids and thus provide experimental system to study the effect of drugs on bile acid secretion and synthesis at cellular level.