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17-β HYDROXYSTEROID DEHYDROGENASE TYPES 1 AND 2
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The article was published on 1999-01-01 and is currently open access. It has received 5 citations till now. The article focuses on the topics: Hydroxysteroid dehydrogenase.read more
Citations
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Molecular Cloning and Characterization of Mouse Estradiol 17β-Dehydrogenase(A-Specific), a Member of the Aldoketoreductase Family.
Deyashiki Yoshihiro,Ohshima Kiyoshi,Nakanishi Masayuki,Sato Kumiko,Matsuura Kazuya,Hara Akira +5 more
TL;DR: A mouse cDNA clone encoding monomeric 17β-hydroxysteroid dehydrogenase (17β-HSD) with A-stereospecificity in hydrogen transfer was reported in this article, which differs from the B-specific dimeric enzyme of human placenta in its ability to catalyze the oxidoreduction of trans-dihydrodiols of aromatic hydrocarbons and carbonyl compounds.
Journal ArticleDOI
Ligand-Based Pharmacophore Modeling and Virtual Screening for the Discovery of Novel 17β-Hydroxysteroid Dehydrogenase 2 Inhibitors
Anna Vuorinen,Roger T. Engeli,Arne Meyer,Fabio Bachmann,Ulrich J. Griesser,Daniela Schuster,Alex Odermatt +6 more
TL;DR: Three of the new, small, synthetic 17β-HSD2 inhibitors showed acceptable selectivity over other related HSDs, and six of them did not affect other HSD’s.
Journal ArticleDOI
Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery.
Gonda Konings,Gonda Konings,Linda Brentjens,Linda Brentjens,Bert Delvoux,Bert Delvoux,Tero Linnanen,Karlijn M. C. Cornel,Karlijn M. C. Cornel,Pasi Koskimies,Marlies Y. Bongers,Marlies Y. Bongers,Roy F.P.M. Kruitwagen,Roy F.P.M. Kruitwagen,Sofia Xanthoulea,Sofia Xanthoulea,Andrea Romano,Andrea Romano +17 more
TL;DR: An up-to-date view of the intracrine estrogen metabolisms, and to a lesser extent that of progestogens and androgens, in the lower female genital tract, including the physiological control of endometrial functions, receptivity, menopausal status and related pathological conditions is given.
Journal ArticleDOI
Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish
Maria Tsachaki,Arne Meyer,Arne Meyer,Benjamin D. Weger,Benjamin D. Weger,Denise V. Kratschmar,Janina Tokarz,Jerzy Adamski,Heinz-Georg Belting,Markus Affolter,Thomas Dickmeis,Alex Odermatt +11 more
TL;DR: Due to the lack of 11-ketosteroid reduction, zebrafish and other teleost fish exhibit a limited tissue-specific regulation of glucocorticoid action, and their androgen production pathway is characterized by sustained 11KT production.
DissertationDOI
A powerful combination of computational methods on the road toward potent non-steroidal inhibitors of steroidogenic enzymes involved in hormone-dependent diseases
TL;DR: In this article, Zusammenfassung et al. included in the thesis included in their contribution report is a discussion of the relationship between the thesis and the paper.
References
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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.
TL;DR: A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets that results in quantitative transfer of ribosomal proteins from gels containing urea.
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
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The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
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Cloning of a novel receptor expressed in rat prostate and ovary.
TL;DR: It is concluded that clone 29 cDNA encodes a novel rat ER, which is suggested be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.