Quantitative analysis of robustness of dynamic response and signal transfer in insulin mediated PI3K/AKT pathway
Shibin Mathew,Ipsita Banerjee +1 more
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TLDR
Using global sensitivity analysis, robustness promoting mechanisms that ensure maintenance of first order or overshoot dynamics of self-renewal molecule, p-AKT and robust transfer of signals from oscillatory insulin stimulus to p- AKT in the presence of noise are identified.About:
This article is published in Computers & Chemical Engineering.The article was published on 2014-12-04 and is currently open access. It has received 12 citations till now. The article focuses on the topics: Negative feedback & PI3K/AKT/mTOR pathway.read more
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VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways
TL;DR: This work provides an approach to direct disease treatment development by providing a better understanding of proteins driving the disease by introducing a computational approach that accurately predicts cellular responses elicited via VEGFR1 signaling.
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PI3K in stemness regulation: from development to cancer.
TL;DR: Current known and unknowns of PI3K-dependent stemness regulation are summarized, by integrating knowledge from the fields of developmental, signalling and cancer biology to better understand the pathway's two-layered and highly context-dependent regulation of cell growth versus stemness.
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ZiBu PiYin recipe prevents diabetes-associated cognitive decline in rats: possible involvement of ameliorating mitochondrial dysfunction, insulin resistance pathway and histopathological changes
TL;DR: ZBPYR showed excellent protective effect against DACD via ameliorating mitochondrial dysfunction, insulin resistance and histopathological changes.
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Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress.
TL;DR: ZBPYR treatment significantly decreased anxious-like behaviors and plasma corticosterone levels, and ameliorated learning and memory impairments of ZDF rats after chronic psychological stress, and modulated the mTOR-autophagy pathway.
References
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Embryonic Stem Cell Lines Derived from Human Blastocysts
James A. Thomson,Joseph Itskovitz-Eldor,Sander S. Shapiro,Michelle A. Waknitz,Swiergiel Jennifer J,Vivienne S. Marshall,Jeffrey M. Jones +6 more
TL;DR: Human blastocyst-derived, pluripotent cell lines are described that have normal karyotypes, express high levels of telomerase activity, and express cell surface markers that characterize primate embryonic stem cells but do not characterize other early lineages.
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Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates
TL;DR: In this article, global sensitivity indices for rather complex mathematical models can be efficiently computed by Monte Carlo (or quasi-Monte Carlo) methods, which are used for estimating the influence of individual variables or groups of variables on the model output.
Book
Process Dynamics and Control
TL;DR: This book discusses the development of Empirical Models from Process Data, Dynamic Behavior of First-Order and Second-Order Processes, and Dynamic Response Characteristics of More Complicated Processes.
Journal ArticleDOI
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
Kevin A. D'Amour,Anne G. Bang,Susan Eliazer,Olivia Kelly,Alan D. Agulnick,Nora G Smart,Mark A. Moorman,Evert Kroon,Melissa K Carpenter,Emmanuel E. Baetge +9 more
TL;DR: A differentiation process that converts human embryonic stem cells to endocrine cells capable of synthesizing the pancreatic hormones insulin, glucagon, somatostatin, pancreatic polypeptide and ghrelin is developed.
Proceedings Article
Biological robustness
Hiroaki Kitano,F. Matsuno +1 more
TL;DR: Insights into inherent properties of robust systems will provide a better understanding of complex diseases and a guiding principle for therapy design.