Open Access
Radiation biology in cancer research
R.E. Meyn,H.R. Withers +1 more
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TLDR
This book contains the proceedings of a symposium held in February and March 1979 and represents a timely appearance of the 40 scientific presentations and conference summary from a rather large meeting.Abstract:
This book contains the proceedings of a symposium held in February and March 1979. The publication of the book in early 1980 represents a timely appearance of the 40 scientific presentations and conference summary from a rather large meeting. The papers are organized into six categories ranging from basic biophysics of radiation damage to new methods and combinations in radiation therapy of human malignancies. This organization, going from the basic mechanisms of radiation damage to new therapy applications, is a logical one, and the relatively large emphasis on papers in the first category is a refreshing change for a symposium of this sort. The quality of editing, production, and illustrations is high.read more
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Book ChapterDOI
Cell death : the significance of apoptosis
TL;DR: It has proved feasible to categorize most if not all dying cells into one or the other of two discrete and distinctive patterns of morphological change, which have, generally, been found to occur under disparate but individually characteristic circumstances.
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Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships
TL;DR: These findings imply that the shape of the dose-survival curve for the target cells whose depletion results in late effects is different from that for target cells for acute effects: as the dose increases the contribution to cell killing from accumulated sublethal injury, relative to killing from single hit events, increases more rapidly in thetarget cells for late effects.
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Effects of radiation on normal tissue: consequences and mechanisms.
TL;DR: Treatments that reduce the risk or severity of damage to normal tissue or that facilitate the healing of radiation injury are being developed, which could greatly improve the quality of life of patients treated for cancer.
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The radiotherapeutic injury – a complex ‘wound’
TL;DR: The principles of organised normal tissue responses during and after radiation therapy, the effect of radiation therapy on these responses, as well as some of the mechanisms underlying the development of recognisable injury are reviewed.
Book ChapterDOI
Tumor promoters and the mechanism of tumor promotion.
TL;DR: This chapter reviews the studies on the mechanism of tumor promotion in mouse skin by croton oil and phorbol diesters and on the effects of these compounds on cell cultures of various types and discusses the findings in the field of tumor promoters during mid- 1979.