Journal ArticleDOI
Radical-initiated polyolefinic cyclizations in linear triquinane synthesis. model studies and total synthesis of (±)-hirsutene
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TLDR
In this article, a novel radical-initiated polyolefinic cyclization approach to linear condensed cyclopentanoids is reported, executed in three stages: (1) Sn2′-anti opening of a vinyl lactone, (2) rapid elaboration to a cyclization precursor, and (3) single step tandem radical cyclization to produce a cis-anticis tricyclo[3.3.0]undecane.About:
This article is published in Tetrahedron.The article was published on 1985-01-01. It has received 104 citations till now. The article focuses on the topics: Radical cyclization & Total synthesis.read more
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Cascade reactions in total synthesis.
TL;DR: The power of cascade reactions in total synthesis is illustrated in the construction of complex molecules and underscore their future potential in chemical synthesis.
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Radicals: Reactive Intermediates with Translational Potential
TL;DR: This Perspective illustrates the defining characteristics of free radical chemistry, beginning with its rich and storied history, and studies from the laboratory are discussed along with recent developments emanating from others in this burgeoning area.
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Kaskadenreaktionen in der Totalsynthese
Kyriacos C. Nicolaou,Kyriacos C. Nicolaou,David J. Edmonds,David J. Edmonds,Paul G. Bulger,Paul G. Bulger +5 more
TL;DR: In this article, ausgewahlte Kaskadenreaktionen in der Naturstoffsynthese erlautert, wobei neuere Anwendungen besonders hervorgehoben werden.
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Radical Cascades Initiated by Intermolecular Radical Addition to Alkynes and Related Triple Bond Systems
TL;DR: In this paper, the authors studied the effect of intermolecular radical cyclizations and multicomponent radical cascades in solution, which are initiated by intermolescular radical addition to C-C triple bond in alkynes as well as to related C?N triple bonds in nitriles and isonitriles, arranged according to the atom that carries the unpaired electron in the attacking radical and cover main group IV-VI elements.
References
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Lanthanides in organic chemistry. 1. Selective 1,2 reductions of conjugated ketones
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The ester enolate Claisen rearrangement. Stereochemical control through stereoselective enolate formation
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Pyridinium p-toluenesulfonate. A mild and efficient catalyst for the tetrahydropyranylation of alcohols
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Nucleophilic and organometallic displacement reactions of allylic compounds: stereo-and regiochemistry
TL;DR: In this paper, stereo and regiochemical aspects of three reaction types: the SN2' reaction (bimolecular nucleophilic substitution with allylic rearrangement); displacement reactions effected by organometallic reagents; the conversion of allylic alcohols into halides.