Journal ArticleDOI
Rapid eye movement sleep alterations in myasthenia gravis
TLDR
The findings suggest a disturbed central mechanism of acetylcholine in myasthenia gravis, which is the putative brain stem transmitter substance involved in the maintenance of REM sleep.Abstract:
The nocturnal sleep patterns of 10 patients with myasthenia gravis and five controls were recorded in the conventional manner for 7 hours on two consecutive nights. One patient was retested 4 weeks after institution of prednisone therapy. All the myasthenics had a significant disturbance in rapid eye movement (REM) sleep cycles. In the patient who was retested after clinically successful prednisone therapy, the REM sleep pattern had become normal. Since acetylcholine is the putative brain stem transmitter substance involved in the maintenance of REM sleep, our findings suggest a disturbed central mechanism of acetylcholine in myasthenia gravis.read more
Citations
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Journal ArticleDOI
Sleep and breathing in neuromuscular disease
Stephen Bourke,Grant Gibson +1 more
TL;DR: Noninvasive ventilation improves sleep quality and breathing in subjects with respiratory muscle weakness, however, the optimal criteria for initiation of ventilation and its role in rapidly progressive neuromuscular diseases are unclear.
Book ChapterDOI
Heterogeneity and regulation of nicotinic acetylcholine receptors.
TL;DR: This chapter focuses on nicotinic acetylcholine receptors (nAChRs), and foscuses on the bases, manifestations, and functional significance of nAChR diversity.
Journal ArticleDOI
Psychiatric screening on a neurological ward.
TL;DR: It is concluded that in populations at high risk for cognitive impairment a tandem screening procedure utilizing tests for both cognitive and emotional disorders is needed.
Journal ArticleDOI
Neuromuscular, autonomic and central cholinergic hyperactivity associated with thymoma and acetylcholine receptor-binding antibody.
TL;DR: This syndrome represents a unique type of autoimmune disease, in which antibodies against the AChR facilitate rather than inhibit cholinergic action, resulting in generalized myokymia, excessive sweating and intermittent psychotic behaviour.
Journal ArticleDOI
Mood and anxiety disorders in patients with myasthenia gravis - Aetiology, diagnosis and treatment
TL;DR: There appears to be an intricate relationship between MG and psychiatric symptoms, and prospective, randomised, controlled pharmaco/psychotherapy studies are needed to better direct the management of patients and, thus, improve quality of life during the course of the illness.
References
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Journal ArticleDOI
A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
TL;DR: Techniques of recording, scoring, and doubtful records are carefully considered, and Recommendations for abbreviations, types of pictorial representation, order of polygraphic tracings are suggested.
Journal ArticleDOI
The first night effect: an EEG study of sleep.
TL;DR: The electroencephalographic records from 43 subjects who slept for four consecutive nights in a laboratory environment showed that the first night of laboratory sleep contains more awake periods and less Stage I-rapid eye movement sleep.
Journal ArticleDOI
EEG sleep patterns as a function of normal and pathological aging in man
Irwin Feinberg,Irwin Feinberg,Richard L. Koresko,Richard L. Koresko,Naomi Heller,Naomi Heller +5 more
TL;DR: It appears that the EEG of sleep may prove to be a diagnostic and research tool of special value to geriatric psychiatry because the quantitative changes in sleep with normal and pathological aging are similar to changes which take place in rate of overall brain metabolism.
Journal ArticleDOI
Sleep patterns in young adults: an eeg study.
TL;DR: EEG sleep stages do not appear in any consistent temporal sequence from night to night in a given subject nor in a group of subjects, and the stage change was usually smooth, moving from one stage to the next when sleep was deepening, but less smooth, often “jumping”.