Journal ArticleDOI
Reduced Thirst after Water Deprivation in Healthy Elderly Men
P. A. Phillips,P. A. Phillips,P. A. Phillips,Barbara J. Rolls,J. G. G. Ledingham,J. G. G. Ledingham,J. G. G. Ledingham,Mary L. Forsling,Mary L. Forsling,Mary L. Forsling,James J. Morton,James J. Morton,James J. Morton,M. J. Crowe,M. J. Crowe,M. J. Crowe,Leopold Wollner,Leopold Wollner,Leopold Wollner +18 more
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TLDR
There is a deficit in thirst and water intake in healthy elderly men, as compared with younger men, although vasopressin osmoreceptor responsiveness is maintained or even increased, and it is suggested that the well-known deficit in urinary concentrating ability that occurs with age reflects renal causes and not a lack of circulating vasoppressin.Abstract:
To determine whether responses to dehydration are altered with age, we investigated the thirst, fluid and electrolyte responses, and hormonal responses to 24 hours of water deprivation in seven healthy active elderly men (67 to 75 years old) and seven healthy young men (20 to 31 years old) who were matched for weight loss during water deprivation. After water deprivation, the older men had greater increases in plasma osmolality, sodium concentration, and vasopressin levels. However, their urinary osmolality was lower and they were less thirsty and drank less after water deprivation, so that their plasma and urine were not diluted to predeprivation levels. Regression analysis indicated increased sensitivity of vasopressin osmoreceptors in the older group, although this difference was not statistically significant. We conclude that after 24 hours of water deprivation, there is a deficit in thirst and water intake in healthy elderly men, as compared with younger men, although vasopressin osmoreceptor responsiveness is maintained or even increased. Our findings also suggest that the well-known deficit in urinary concentrating ability that occurs with age reflects renal causes and not a lack of circulating vasopressin.read more
Citations
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Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications
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TL;DR: This review examines the current knowledge of water intake as it pertains to human health, including overall patterns of intake and some factors linked with intake, the complex mechanisms behind water homeostasis, and the effects of variation in water intake on health and energy intake, weight, and human performance and functioning.
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Excess hospital admissions during the July 1995 heat wave in Chicago
TL;DR: The majority of excess hospital admissions were due to dehydration, heat stroke, and heat exhaustion, among people with underlying medical conditions, and short-term public health interventions to reduce heat-related morbidity should be directed toward these individuals.
References
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Book
Statistical Principles in Experimental Design
TL;DR: In this article, the authors introduce the principles of estimation and inference: means and variance, means and variations, and means and variance of estimators and inferors, and the analysis of factorial experiments having repeated measures on the same element.
Journal ArticleDOI
Statistical Principles in Experimental Design
TL;DR: This chapter discusses design and analysis of single-Factor Experiments: Completely Randomized Design and Factorial Experiments in which Some of the Interactions are Confounded.
Book
McCance and Widdowson's The composition of foods
A. A. Paul,D. A. T. Southgate +1 more
TL;DR: The British tables of Paul and Southgate provide by far the most extensive introductory and explanatory material with the tables and is a resource which is often utilized.
Journal ArticleDOI
Effect of age and high blood pressure on baroreflex sensitivity in man.
TL;DR: Eight subjects who had normal blood pressure at the time of testing but whose pressure had been elevated in the past, had reflex sensitivities significantly less than expected in persons of the same age and mean arterial pressure.
Journal ArticleDOI
Effect of aging on plasma renin and aldosterone in normal man
Peter Weidmann,Sylvianne De Myttenaere-Bursztein,Morton H. Maxwell,José Jayme Galvão de Lima +3 more
TL;DR: It is concluded that aging may cause a decrease in circulating renin, with parallel lowering of plasma aldosterone concentrations, regardless of the presence or absence of an inverse relationship with blood pressure.