The standardisation of terminology of lower urinary tract function: Report from the standardistation sub-committee of the International Continence Society.

The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society.

Introduction and hypothesis Next to existing terminology of the lower urinary tract, due to its increasing complexity, the terminology for pelvic floor dysfunction in women may be better updated by a female-specific approach and clinically based consensus report. Methods This report combines the input of members of the Standardization and Terminology Committees of two Inter

http://bethshelly.com/docs/standardization-2009-IUGA-ICS-Terminology-PF-dysfunction.pdf

An international urogynecological association (IUGA)/international continence society (ICS) joint report on the terminology for female pelvic floor dysfunction

Next to existing terminology of the lower urinary tract, due to its increasing complexity, the terminology for pelvic floor dysfunction in women may be better updated by a female-specific approach and clinically based consensus report. This report combines the input of members of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted at intervals by many external referees. Appropriate core clinical categories and a subclassification were developed to give an alphanumeric coding to each definition. An extensive process of 15 rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). A terminology report for female pelvic floor dysfunction, encompassing over 250 separate definitions, has been developed. It is clinically based with the six most common diagnoses defined. Clarity and user-friendliness have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Female-specific imaging (ultrasound, radiology, and MRI) has been a major addition while appropriate figures have been included to supplement and help clarify the text. Ongoing review is not only anticipated but will be required to keep the document updated and as widely acceptable as possible. A consensus-based terminology report for female pelvic floor dysfunction has been produced aimed at being a significant aid to clinical practice and a stimulus for research.

An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction

Advanced Statistical Methods in Biometric Research.

A radioimmunoassay has been developed that permits reliable measurements of plasma arginine vasopressin (AVP) at concentrations as low as 0.5 pg/ml in sample volumes of 1 ml or less. Nonhormonal immunoreactivity associated with the plasma proteins is eliminated by acetone precipitation before assay, leaving unaltered a component that is immunologically and chromatographically indistinguishable from standard AVP. Storage of plasma results in a decline in AVP concentration and, thus, must be carefully regulated. The plasma AVP values obtained by our method approximate the anticipated levels and vary in accordance with physiologic expections. In recumbent normal subjects, plasma AVP ranged from (mean ±SD) 5.4±3.4 pg/ml after fluid deprivation to 1.4±0.8 pg/ml after water loading, and correlated significantly with both plasma osmolality (r=0.52; P<0.001) and urine osmolality (r=0.77; P<0.001). After fluid restriction, plasma AVP was uniformly normal relative to plasma osmolality in patients with nephrogenic diabetes insipidus and primary polydipsia but was distinctly subnormal in all patients with pituitary diabetes insipidus. The infusion of physiologic amounts of posterior pituitary extract caused a dose-related rise in plasma vasopressin that afterwards declined at the expected rate (t½=22.5±4 min). We conclude that, when used appropriately, our radioimmunoassay method provides a useful way of assessing AVP function in man.

/pdf/development-and-clinical-application-of-a-new-method-for-the-seir0yifws.pdf

Development and Clinical Application of a New Method for the Radioimmunoassay of Arginine Vasopressin in Human Plasma

https://onlinelibrary.wiley.com/doi/pdf/10.1002/nau.10053

The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society.

The osmoregulation of vasopressin.

Publisher Summary
This chapter describes anti-diuretic hormone arginine vasopressin (AVP), lysine vasopressin (EVP), urinary AVP, plasma AVP-osmolality, and the chromatographic behavior of purified bovine AVP on Sephadex G-15 with different eluting solvents or sample composition. As immunoassay methods can be used successfully to develop simple and accurate assays, plasma AVP has re-stimulated much investigative interest and, as a consequence, many other laboratories are beginning to develop their own assay procedures. It has been known for almost 30 years that the secretion of AVP can be influenced by a number of factors, including changes in blood osmolality, volume, and pressure. However, the relative potency of these variables and the way in which they interact in regulating secretion of the hormone under different conditions of salt and water balance has been a subject of some dispute. The advent of the immunoassay technique has now made it possible to begin to define these aspects of AVP physiology in more precise and comprehensive terms. The osmoregulation of AVP can be readily understood by analyzing the relationship between plasma AVP and plasma osmolality under different conditions of water balance.

The regulation of vasopressin function in health and disease.

https://www.amjmed.com/article/0002-9343(82)90825-7/pdf

Gary L. Robertson

Papers

Development and Clinical Application of a New Method for the Radioimmunoassay of Arginine Vasopressin in Human Plasma

The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society.

The osmoregulation of vasopressin.

The regulation of vasopressin function in health and disease.

Neurogenic disorders of osmoregulation