Showing papers in "Kidney International in 1975"

TL;DR: It is concluded that aging may cause a decrease in circulating renin, with parallel lowering of plasma aldosterone concentrations, regardless of the presence or absence of an inverse relationship with blood pressure.

TL;DR: Electrostatic repulsion of charged macromolecules by some component of the glomerular capillary wall, perhaps the negatively charged sialoprotein which coats glomersular epithelial cells, might account for the enhanced transmural passage of albumin.

TL;DR: The experimental study of renal function and metabolism requires the dissociation of extrarenal and intrarenal control mechanisms by stepwise suppression of the messages transmitted to the kidneys by humoral, hormonal, hemodynamic or nervous pathways by means of progressive isolation of these organs.

TL;DR: It is proposed that the massive, early proteinuria in PAN nephrosis may be primarily due to a glomerular epithelial lesion, leading to scattered focal defects in the external covering of the GBM.

TL;DR: The course of the disease in most adult patients is long-standing but its clinical expression is mild, with little evidence of progression over decades, and it is therefore of note that the disease began during childhood in several patients of this report.

TL;DR: There is evidence from work with particulate tracers (particularly that with dextrans in nephrotic animals) which supports the monitoring function proposed for the epithelium, and the bulk of the evidence available at present favors the basement membrane as the primary filtration barrier in the glomerulus.

TL;DR: These two varieties of MPGN are at present not distinguished one from another in most clinical studies because it may be difficult to recognize MPGN with DIMD on light microscopy.

TL;DR: Analysis of protein content of proximal tubular fluid by ultramicro disc electrophoresis and total protein excretion rates both in control conditions and during angiotensin infusion to the rat describe a protein reabsorptive system normally operating near capacity.

TL;DR: Some overproducers of urate developed varying degrees of renal insufficiency while others members of the same family with the same genetic mutation retained normal renal function.

TL;DR: It is concluded that some cases of focal glomerular sclerosis are associated with severe damage to podocytes which may be caused by drugs, infection or unknown factors and may contribute to the development and progression of theglomerular lesions.

TL;DR: CMV infection was due either to reactivation of latent infection or was transmitted along with the renal allograft and manifested as a primary infection.

TL;DR: In patients with GFR less than 5 ml/min but greater than 1 ml/Min, 125I-iothalamate clearance showed the best correlation with inulin clearance, however, creatinine clearance correlated better withinulin clearance than urea clearance and as well as urea + creatininine/2.

TL;DR: It has been proposed that the acute increase or decrease of extracellular volume can result in "dilution acidosis" or "contraction alkalosis" purely as a result of changes in the volume of distribution of the bicarbonate present in this fluid compartment.

TL;DR: The results indicate that chronic acidosis elevates iPTH mainly by producing hypercalciuria and that acidosis itself is not a primary stimulus to PTH secretion.

TL;DR: In this paper, the effect of kidney dialysis on cardiovascular disease was investigated in patients on chronic maintenance dialysis, and the results showed an increased risk of death from cardiovascular disease.

TL;DR: The changes in post-uninephrectomy renal handling of phosphate are not due to an increase in parathyroid hormone secretion, and the increase in Tmglucose, Tmpah, Cphosphate, uric acid, CH2O, UH + V increased significantly, after unineph rectomy.

TL;DR: There is now compelling evidence, derived from experimental models as well as human disease, that tubular and interstitial lesions can result from immune complexes or from autoantibodies against tubular basement membrane constituents (anti-TBM disease).

TL;DR: The findings are consistent with the interpretation that in patients with SLE nephritis immune deposits, presumably containing DNA-anti-DNA complexes, localize in peritublular capillaries, TBM and interstitum, thereby producing an inflammatory reaction which contributes to development and evolution of renal diseases.

TL;DR: The studies are interpreted to indicate that the impairment in renal function in this model is due to both leakage of filtrate across damaged tubular epithelium and a modest decrease in nephron GFR.

TL;DR: The intrarenal localization of 3 H-angiotensin II after intraaortic administration in anesthetized rats has been studied by autoradiography and the possibility of an action of angiotens in II at the level of the mesangial cells is discussed.

TL;DR: A morphometric technique is used to estimate the absolute and relative surface areas of the brush border microvilli and cell walls bordering lateral intercellular spaces in isolated, perfused proximal tubule from rabbit.

TL;DR: The data indicate that the increased rate of ammoniagenesis which occurs following nephron reduction is markedly influenced by dietary protein content and a lack of enhanced GLDH activity may underlie the lack of increased ammonia production of low protein-fed rats following ne phrectomy.

TL;DR: The mechanism for enhanced compensatory renal growth in young animals does not involve glomerular neogenesis since there was no evidence for formation of additional nephrons following nephrectomy either in weanling or neonatal animals.

TL;DR: It is suggested that renal prostaglandins protect against the development of G-induced acute renal failure (a circulatory type of renal failure) in this animal model.

TL;DR: Evidence of both generalized and localized intravascular coagulation can be found in a wide variety of diseases which cause lesions of glomeruli, arteries and arterioles in the kidney, including acute tubular necrosis and malignant hypertension.